Short telomeres in peripheral blood leukocytes (PBLs) are associated with aging and age-related diseases. It has been studied as a potential biomarker for age-related diseases such as cancer, cardiovascular disease, chronic lung disease, diabetes mellitus, and many other diseases. CD BioSciences provides telomere length measurement service for PBLs, thereby enabling scientists to study the possible association between leukocyte telomere length and aging and age-related diseases as well as develop its application use.
Telomere Length Variation in PBLs
PBLs are a group of closely related cells that include neutrophils, monocytes, eosinophils, basophils, and lymphocytes. These cells are constantly moving throughout the body. They are usually obtained by collecting fasting peripheral venous blood and are often used as samples for physical function assessment.
Although not fully understood, neurological disorders, cardiovascular diseases, immune-related disorders, and other chronic degenerative diseases associated with aging as well as the normal aging process may be reflected in changes in PBL telomere length.
Workflow of Telomere Length Measurement for PBLs
- Sample preparation
Samples must be freshly collected and sent to us within 24-36 hours after collection according to shipping conditions.
- Telomere length measurement
We offer a range of methods for telomere length detection in PBLs, such as terminal restriction fragment (TRF), quantitative polymerase chain reaction (qPCR), and fluorescence in situ hybridization (FISH) techniques. The relative telomere length, average telomere length, and telomere distribution are measured in triplicate for each sample.
- Statistical analysis.
We can use various significant difference tests to support the search for differences in telomere length between different cell samples. For multiple regression analysis with the telomere length of different samples as the response variable.
- Delivery reports
Our clients will receive a comprehensive report of the test results in the shortest possible time. This includes the mean telomere length of the samples and the interpretation of these results as well as an analysis report of the correlation study.
Applications of PBL Telomere Length Measurement in Aging Studies
- Telomere assays for PBLs play an important role in aging and age-related disease research. They may serve as biomarkers as well as provide a better understanding of the age or aging process of the sample cells.
- PBL's telomere length test can help to understand the overall aging process of the test subject and the likelihood of interventions or medications for aging-related diseases.
For many years, CD BioSciences has been providing exceptional scientific services to research institutions and pharmaceutical companies around the world. We have a proven technology platform and comprehensive service offerings in the field of telomere analysis. Our clients can fill out the inquiry form directly and send it to us or call us directly. Contact us to learn more about our telomere measurements on human samples.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
