Low molecular weight molecules in biological systems are often referred to as metabolites and they act as end products or intermediates of cellular metabolism. Levels of metabolites such as hormones, lipids, glucose, amino acids, and cholesterol in the human body can be used as molecular biomarkers of aging and can be used to understand the physiological changes that occur in individuals as they age, the aging process, and the onset of age-related diseases.
CD BioSciences provides age-related metabolite biomarker discovery services for identifying potential biomarkers and evaluating their performance. Our clients also can select their biomarkers or set up hold samples for flexible evaluation and validation.
Aging Metabolite Biomarkers in Various Biological Samples
Our metabolomic analysis allows systematic assessment of changes in small molecules of aging and proposes new markers to identify the early stages of aging and age-related diseases. We establish a link between different molecular mechanisms and aging by studying metabolites in different biological samples. The following table summarizes some of the metabolite markers currently explored.
| Biological samples |
Aging metabolite biomarkers |
Blood
(Thousands of metabolites) |
NAD+, lipids, amino acids, glucose, essential trace elements, etc. |
Urine
(End products of various metabolites) |
Citrate, succinate, acetone, equine urate, kynurenate, ferulic acid sulfate, octanedioic acid, cresyl sulfate, trace elements, etc. |
Feces
(Microbial load) |
Microbiota-driven metabolites of interest. |
Our Metabolite Biomarker Discovery Services
Changes in metabolites are important early indicators of aging and related diseases, and the use of metabolomics tools to assess changes in small molecules in natural aging and disease models can provide major clues for early diagnosis and prediction.
We analyze aging-related metabolites and evaluate these differential metabolites to explore new markers to identify aging. Using state-of-the-art mass spectrometry instrumentation and techniques for sensitive and accurate detection, we can efficiently process the complex data sets generated by these analyses.
Identification and pathway enrichment analysis of aging-related metabolites
We identify metabolites significantly correlated with age in data collection and sample assays, use statistical methods to screen and identify the top-ranked metabolites among all metabolite species, and then perform pathway enrichment analysis.
Testing and verification
We detect and identify stable metabolites in training and test sets, and calculate correlations with age through sample validation and analysis.
Our Advantages
- Each project begins with a consultation with a scientific professional to determine your analytical needs, meeting demands including regulatory requirements and project cycle time.
- Our targeted assays cover over 1000 metabolite molecules across a wide range of metabolic pathways and physiological processes and can be customized to fit any of your applications.
- A combination of experience, expertise, and innovative technologies to assist clients in advancing the frontiers of metabolomics and aging research.
Metabolomics can aid in the diagnostic prediction of aging and disease by suggesting the most likely multiple biomarkers. CD BioSciences provides biomarker discovery services for aging metabolomics to reveal its diversity and provide valuable biomarkers for aging-related diagnostics and therapy development. If you are interested in our services, please feel free to contact us or make an online inquiry.
Reference
- Adav S S and Wang Y. Metabolomics Signatures of Aging: Recent Advances. Aging and Disease, 2019, 12 (2): 646-661.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
