Aging-Related Neurodegenerative Diseases

Aging-Related Neurodegenerative Disease Research and Drug Development

Aging is the primary risk factor for neurodegenerative diseases (NDs), such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. The aging process is associated with cellular and molecular changes that can contribute to the onset and progression of neurodegenerative conditions. In recent years, there has been a surge in research and development (R&D) efforts to understand the underlying pathogenesis, identify potential biomarkers, and develop and discover drugs for aging-related NDs.

CD BioSciences offers a wide range of specialized services tailored to address the unique challenges posed by aging-related NDs. We help our clients unravel the pathogenesis of aging-related NDs. Our comprehensive capabilities also encompass various stages of the drug development process, from early target identification to preclinical efficacy and safety assessments.

Aging-Related Neurodegenerative Diseases

Our R&D Services by Type of Aging-Related NDs

Aging-related NDs encompass a wide range of conditions, each with distinct clinical features and pathological hallmarks. While each disease has unique characteristics, they share a common theme of progressive neuronal loss and dysfunction.

Alzheimer's disease (AD). Our team of scientists and researchers work diligently to investigate the underlying pathogenesis, biomarkers, and potential therapeutic interventions for AD.

Alzheimer’s Disease

Parkinson's disease (PD). We conduct preclinical research to investigate the causes and progression of PD, identifying potential drug targets and therapeutic strategies.

Parkinson's Disease

Huntington's disease (HD). We actively engage in R&D initiatives focused on Huntington's disease, a genetic neurodegenerative disorder characterized by motor, cognitive, and psychiatric symptoms.

Huntington's Disease

Amyotrophic lateral sclerosis (ALS). We are committed to advancing R&D efforts for ALS, also known as Lou Gehrig's disease.

Amyotrophic Lateral Sclerosis

Pathogenic Mechanism Analysis Services for Aging-Related NDs

Employing our technologies and expertise, CD BioSciences provides comprehensive analysis services of the pathogenesis of aging-related NDs. We aim to help clients identify potential targets for intervention and develop innovative therapies. Through advanced molecular and cellular techniques, we offer reliable services for the following key processes.

Analysis of synaptic dysfunction. We offer electrophysiological techniques and high-resolution imaging services to investigate how aging affects synaptic plasticity and neurotransmission in NDs. With high-throughput screening assays, our services also explore the role of synaptic proteins, neurotransmitters, and receptors in disease progression.
Analysis of protein misfolding and aggregation. Based on our proteomic services, we help our clients study the impact of aging on protein homeostasis, which can lead to misfolding and aggregation of proteins like amyloid beta and tau. We also examine how aging-related changes in protein clearance pathogenesis contribute to neurodegeneration.
Analysis of inflammation and immune responses. Our research team provides the exploration of the crosstalk between aging-related immune dysregulation and neuroinflammation in diseases like Alzheimer's and Parkinson's. We specialize in investigating the role of microglia, astrocytes, and peripheral immune cells in mediating neurodegenerative processes with aging.
Analysis of oxidative stress and mitochondrial dysfunction. Our services assess the impact of aging on mitochondrial function and dynamics in neurodegenerative conditions. We help clients study the role of reactive oxygen species, antioxidants, and mitochondrial quality control pathogenesis in disease pathogenesis.

Biomarker Identification Services for Aging-Related NDs

At CD BioSciences, we offer comprehensive biomarker identification and analysis services to aid in the advancement of aging-related ND research. Our expertise spans the identification and validation of biomarkers from various sources, including cerebrospinal fluid, blood, and neuroimaging data. By leveraging technologies such as proteomics, genomics, and metabolomics, we strive to discover and validate robust biomarkers that can facilitate disease detection, track disease progression, and assess treatment response.

Disease Model Customization Services for Aging-Related NDs

To mimic the complex nature of aging-related NDs, CD BioSciences helps clients develop a wide range of customized experimental models. Our models enable clients to investigate pathogenesis, evaluate potential therapeutics, and assess treatment efficacy.

Cell-based model customization
Animal model customization

Drug Discovery and Development Services for Aging-Related NDs

The discovery and development of effective therapeutics for aging-related NDs are paramount to combat these devastating conditions. CD BioSciences offers a comprehensive suite of services to support drug discovery and development efforts. Our multidisciplinary team of experts collaborates closely with clients to design and execute preclinical studies, including target validation, hit identification, lead optimization, and efficacy assessment. Through rigorous in vitro and in vivo testing, we evaluate the safety, pharmacokinetics, and efficacy of potential drug candidates, providing valuable insights for subsequent clinical trials.

Behavioral and Cognitive Assessment Services for Aging-Related NDs

Assessing behavioral and cognitive functions is crucial for understanding disease progression and evaluating treatment outcomes in aging-related NDs. CD BioSciences provides a wide array of behavioral and cognitive assessment tools to facilitate research in this area. These assessments encompass motor function tests, memory and learning tasks, anxiety and depression assays, and social behavior evaluations. By employing these assessments in conjunction with our experimental models, we gain a comprehensive understanding of the effects of potential therapeutics on disease-related behaviors and cognitive impairments.

Aging-related NDs present significant challenges to individuals, families, and healthcare systems worldwide. Through our dedicated research and development services at CD BioSciences, we strive to advance the understanding of these debilitating conditions and contribute to the development of effective therapeutics. If you are interested in our services, please feel free to contact us or make an online inquiry.