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All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

Analysis of Age-Related Changes of Glucose Homeostasis in Animal Models

INQUIRY

Glucose is a fundamental energy source for the body's cells, and the maintenance of its homeostasis is critical for overall health. Aging is associated with alterations in glucose metabolism. Impairment of insulin secretion and action has been demonstrated in aging individuals. The study of laboratory animals has significantly advanced the understanding of the physiological mechanisms underlying these age-related alterations.

CD BioSciences is proud to offer a comprehensive suite of glucose homeostasis analysis services tailored for aging research in animal models. Our team of seasoned experts is well-equipped to help clients understand the complex mechanisms of glucose regulation that underlie the aging process.

Glucose level measurement

Glucose Level Analysis in Aging

We offer a series of glucose level analysis services to monitor and evaluate glucose concentrations in animal models for aging research. Using liquid chromatography-mass spectrometry (LC-MS) and enzymatic assays, we generate detailed glucose profiles that reflect the metabolic state of aging models. Our services help clients identify age-related dysregulation in glucose metabolism and pinpoint potential therapeutic targets for metabolic diseases.

Insulin level measurement

Insulin Level Analysis in Aging

Insulin plays a pivotal role in glucose homeostasis, and its dysregulation is a hallmark of aging-related metabolic diseases. To support related studies, we offer comprehensive insulin level analysis services using enzyme-linked immunosorbent assays (ELISA) and radioimmunoassays (RIA) to quantify insulin concentrations in animal models. Our deliverables include validated protocols, high-quality insulin concentration data, and in-depth analysis, providing essential information for evaluating insulin sensitivity and pancreatic beta-cell function in aging.

Glucose tolerance test

Glucose Tolerance Test in Aging

Our company offers glucose tolerance test (GTT) services specifically designed for aging studies. We administer certain concentrations of glucose solution in animal models and measure blood glucose levels at regular intervals. Our experts analyze the data to evaluate the efficiency of glucose uptake and clearance, providing insights into identifying age-related impairments in glucose metabolism and evaluating the efficacy of anti-aging therapeutics.

Insulin tolerance test

Insulin Tolerance Test in Aging

Complementing our GTT services, we also provide insulin tolerance test (ITT) services to evaluate tissue responsiveness to insulin. Following insulin administration, we monitor blood glucose levels over time to determine insulin sensitivity. Our team assists clients in comparing insulin tolerance profiles between aged and young animals and correlating the results with other age-related metabolic indicators, such as body weight, body composition, and glucose/insulin concentrations.

Pyruvate tolerance test

Pyruvate Tolerance Test in Aging

We offer pyruvate tolerance test (PTT) services to assess gluconeogenic capacity in animal models for aging research. Our test services help clients unveil gluconeogenesis, the process by which the body synthesizes glucose from non-carbohydrate precursors such as pyruvate. Our PTT services also support comparative studies between animal models or treatment groups. We provide detailed statistical analyses to ensure that results are robust, actionable, and scientifically valid.

CD BioSciences is committed to advancing the understanding of glucose homeostasis in aging studies. If you are interested in our services, please feel free to contact us or make an online inquiry.

Reference

Giridharan NV. Glucose & energy homeostasis: Lessons from animal studies. Indian J Med Res, 2018, 148 (5): 659-669.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.