Unlike blood, urine can be collected non-invasively, allowing longitudinal studies with minimal stress to animals. Urine contains a wealth of metabolic byproducts and biomarkers, reflecting the health and functionality of multiple organ systems, particularly the kidneys and urinary tract. By analyzing changes in urine composition, researchers can monitor renal function, detect early signs of age-related diseases, and assess metabolic health. Additionally, urine analysis can reveal shifts in hormone excretion and the presence of metabolic waste products, thereby unveiling the metabolic state and efficiency of animals.
Utilizing advanced technologies, CD BioSciences provides our clients with analysis of age-related urine changes in animal models. As a leading provider of aging research services, we understand that comprehensive, data-driven assessments are critical to advancing breakthroughs in the field of longevity science.
Sample Requirements
To ensure the accuracy and reliability of our urine analysis services, we have established strict sample collection and handling protocols. Our expert team will work closely with clients to guide them through the sample preparation process, guaranteeing the integrity of samples throughout the entire workflow.
How Do We Analyze Age-Related Urine Changes?
Basic urine analysis services
The foundation of our urine analysis services lies in the comprehensive evaluation of basic urine parameters, such as pH levels, specific gravity, and glucose concentration. Our basic urine analysis services offer insights into the health and functional status of the animal aging models, allowing clients to identify early signs of age-related physiological changes.
Protein analysis services
Our protein analysis techniques allow quantification of various urinary proteins, such as albumin and creatinine. Our team at CD BioSciences also supports clients in quantifying a range of specialized urinary biomarkers in animal models, such as neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1), which uncover the extent and nature of age-related kidney impairment.
Metabolomic profiling services
Leveraging the power of mass spectrometry technologies, we help clients conduct comprehensive metabolomic analyses of urine samples by detecting and quantifying a wide range of metabolites, including amino acids, lipids, carbohydrates, and other small molecules. Our experts analyze the patterns and changes in these metabolic signatures to identify the specific metabolic pathways in aging. Additionally, we assist clients in uncovering novel biomarkers, unveiling underlying biochemical pathways, and identifying potential therapeutic targets by mapping the intricate metabolic signatures associated with the aging process.
Our Tools for Urine Analysis Services
We are committed to utilizing advanced analysis technologies to ensure the quality of our urine analysis services. Our dedicated team of scientific experts operates a wide array of tools, including:
- High-performance liquid chromatography (HPLC) for quantification of key urinary compounds.
- Liquid chromatography-mass spectrometry (LC-MS) for comprehensive metabolomic profiling.
- Enzyme-linked immunosorbent assay (ELISA) for targeted detection and quantification of specific urinary biomarkers.
- Automated urine analyzers for efficient, high-throughput processing of urinalysis parameters.
At CD BioSciences, our comprehensive urine analysis services, integrated with advanced technologies and scientific expertise, provide a powerful platform for advancing aging research in animal models and preclinical studies. If you are interested in our services, please feel free to contact us or make an online inquiry.
Reference
- Nkuipou-Kenfack E, et al. The use of urinary proteomics in the assessment of the suitability of mouse models for aging. Sci PLoS One, 2017, 12 (2): e0166875.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
