Aging is a multifaceted process involving a gradual decline in physiological function, which includes disruptions to metabolic pathways such as glucose metabolism. Animal models provide a valuable tool for investigating the mechanisms behind age-related metabolic changes and for testing potential therapeutic interventions. Glucose tolerance tests (GTTs) are a standard method used in preclinical research to assess how quickly the body can clear glucose from the bloodstream, which is essential for evaluating glucose homeostasis.
At CD BioSciences, our comprehensive suite of glucose tolerance test services enables in-depth evaluation of glucose homeostasis in animal models of aging, enabling clients to understand the complex physiological alterations that occur over time.
Overview of Glucose Tolerance Test Services
Oral glucose tolerance tests (OGTTs)
The oral glucose tolerance test is a widely accepted method for assessing whole-body glucose tolerance, particularly relevant in aging research where glucose metabolism often declines with age. In this test, animals undergo a fasting period followed by administration of a standardized glucose solution. We collect blood samples at specific intervals (e.g., 0, 15, 30, 60, 90, 120 minutes) to measure glucose levels. Our OGTT service enables clients to assess age-related impairments in glucose tolerance and metabolic flexibility in animal models.
Intraperitoneal glucose tolerance tests (IPGTTs)
Following a fasting period, glucose is injected intraperitoneally. We then collect blood samples at predetermined intervals to monitor glucose levels. Our services are ideal for assessing insulin sensitivity and pancreatic function in aging models, where oral intake may be compromised.
Intravenous glucose tolerance tests (IVGTTs)
Our intravenous glucose tolerance test (IVGTT) services are specifically designed for preclinical aging studies, achieving a rapid and controlled increase in blood glucose levels. We administer glucose intravenously, and blood samples are collected at various time points to measure glucose and insulin levels. Our test helps clients measure insulin secretion and glucose clearance rates, and pancreatic β-cell function, providing critical insights into age-related changes in insulin sensitivity and metabolic regulation in animal models.
Applications of Glucose Tolerance Tests in Aging Research
- Investigating the impact of aging on glucose regulation. Our glucose tolerance test services can reveal age-associated alterations in glucose tolerance, insulin sensitivity, and related metabolic parameters.
- Evaluating the efficacy of anti-aging interventions. We offer glucose tolerance test services to evaluate the efficacy of various interventions, such as dietary modifications or pharmacological treatments, in mitigating age-related impairments in glucose homeostasis and improving metabolic health in animal models.
- Facilitating translational research. The data generated from our glucose tolerance test services in animal models can be leveraged to inform subsequent human clinical studies, bridging the gap between preclinical and clinical research and accelerating the translation of findings to improve human healthy aging.
At CD BioSciences, we take great pride in our commitment to excellence and our ability to deliver customized, high-quality glucose tolerance test services that enable researchers to unravel the complexities of aging and its impact on metabolic health. If you are interested in our services, please feel free to contact us or make an online inquiry.
Reference
- Kennard MR, et al. The glucose tolerance test in mice: Sex, drugs, and protocol. Diabetes Obes Metab, 2022, 24(11): 2241-2252.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
