Aging is a biological process that affects most cells, organisms, and species. Telomeres, located at the end of chromosomes, have been postulated as a universal biological clock that shortens in parallel with aging in cells. Telomeres shorten as cells age. They consist of an evolutionarily conserved repetitive nucleotide sequence ranging in length from a few hundred base pairs in yeast to several kilobase pairs in vertebrates.
The study of telomere biology in the context of aging is of paramount importance in understanding the molecular mechanisms underlying aging and age-related diseases. CD BioSciences is dedicated to providing comprehensive telomere biology analysis services, enabling researchers to delve deep into the intricate world of telomeres.
Telomere Length Analysis Services in Aging
CD BioSciences offers telomere length analysis services utilizing advanced techniques such as terminal restriction fragment (TRF), quantitative polymerase chain reaction (qPCR), and fluorescence in situ hybridization (FISH). Our methods allow for accurate and precise measurement of telomere length, providing valuable insights into the correlation between telomere length and aging processes.
Our company provides telomere length measurement services for various species, including humans, non-human primates (NHPs), mice, Drosophila, and nematodes. We analyze the connection between telomere length and different aging factors, as well as its correlation with age-related diseases. In addition, we also provide animal studies services on environmental factors, diet factors, and behavioral factors affecting telomere length to explore the mechanisms that influence telomere shortening.
Telomere Structure Analysis Services
CD BioSciences provides cutting-edge telomere structure analysis services, leveraging high-resolution imaging technologies, high-resolution mass spectrometers, immunofluorescence staining, and bioinformatics tools. By examining the architecture of telomeres at the molecular level, our clients can gain a deeper understanding of how telomere structure changes with age and its implications for age-related pathologies.
Our advanced techniques enable precise quantification of shelterin protein expression levels, such as TRF1, TRF2, TIN2, POT1, TPP1, and RAP1. We offer comprehensive analysis services that span sample collection and preparation, TERT protein analysis, and meticulous data interpretation. Our comprehensive profiling analysis includes the identification of novel RNA transcripts and the characterization of their expression patterns across different cell types and tissues.
Functional Analysis of Telomeres and Telomerase
CD BioSciences offers comprehensive functional analyses of telomeres and telomerase activity, allowing researchers to assess the functionality of these critical components in aging processes. We offer comprehensive telomerase maturation and assembly analysis services. In telomere replication analysis, our services focus on semi-conserved replication analysis of telomeric DNA and telomere end resection analysis. Through high-throughput proteomic analyses and advanced bioinformatics tools, we delineate the dynamic changes in telomere-associated protein complexes. Additionally, we employ comprehensive assay systems and cell-based models to dissect the molecular mechanisms underlying telomere deprotection during aging.
In Vitro Analysis of Compounds Affecting Telomeres
CD BioSciences excels in providing in vitro analysis of compounds targeting telomeres, offering a robust platform for evaluating the effects of potential anti-aging agents on telomere function and stability. Our in-depth analysis aids in identifying promising compounds, including natural compounds, antioxidants, and therapeutic drugs, for further development aimed at mitigating age-related deterioration.
The study of telomere biology in aging is an ever-evolving field. CD BioSciences remains dedicated to empowering our clients with unparalleled telomere analysis services, ultimately contributing to the advancement of anti-aging strategies and therapies. We prioritize precision, reliability, and innovation, ensuring that our clients receive actionable insights to drive groundbreaking discoveries in aging research. If you are interested in our services, please feel free to contact us or make an online inquiry.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
