Analysis of Nicotinamide Adenine Dinucleotide in Aging

Nicotinamide adenine dinucleotide (NAD⁺) is a coenzyme that plays a critical role in cellular metabolism, particularly within the mitochondria, the cell's powerhouse. NAD⁺ is involved in various enzymatic reactions, acting as an electron carrier and participating in redox reactions in various metabolic pathways. However, with age, NAD⁺ levels decline, leading to a gradual breakdown of cellular functions. This decline is associated with a range of age-related diseases and the overall aging process.

CD BioSciences is proud to offer a comprehensive range of NAD⁺ analysis services, aimed at unraveling the intricate role of NAD⁺ in the aging process. We harness advanced technological platforms, empowering us to conduct reliable NAD⁺ analyses.

Overview of Our Nicotinamide Adenine Dinucleotide Analysis Services in Aging

Detection of NAD⁺ levels during senescence

Using high-performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS), we provide NAD⁺ level detection services during senescence in model organisms such as nematodes and mice. Through meticulous analysis, we aim to delineate the dynamics of NAD⁺ levels during the aging process, providing invaluable insights into its potential role in age-related physiological changes.

Analysis of the role of NAD⁺ in the aging-related immune system

Through advanced techniques such as flow cytometry, cytokine profiling, and immune cell metabolism assays, our analysis aims to elucidate the influence of NAD⁺ on immune cell activity and its contribution to age-related immune dysregulation. By studying NAD⁺-dependent metabolic pathways in immune cells, we aim to uncover how NAD⁺ influences immune cell energetics, redox signaling, and the overall immune-metabolic landscape during aging.

Analysis of the role of NAD⁺ in aging-related diseases

CD BioSciences delves into the intricate interplay between NAD⁺ and aging-related diseases. Our in-depth analysis strives to unravel the involvement of NAD⁺ in age-associated pathologies, including neurodegenerative diseases, metabolic disorders, and cardiovascular conditions.

Deliveles of Nicotinamide Adenine Dinucleotide Analysis Services

Clients partnering with CD BioSciences can expect meticulously curated deliverables, including detailed experimental procedures, raw data, explicit pictures, and comprehensive data interpretation by our proficient team of scientists.

• Comprehensive NAD⁺ quantification reports. We provide detailed reports outlining the quantitative analysis of NAD⁺ levels in biological samples. The reports provide precise measurements of NAD⁺ concentrations, providing relevant mass spectrometry parameters, mass spectrometry images, and raw data.
• NAD⁺ precursors and metabolites evaluation. In addition to measuring total NAD⁺ levels, we also offer NAD⁺ profiling services. Our services involve evaluating the levels of different NAD⁺ precursors and metabolites, such as nicotinamide riboside (NR), nicotinamide mononucleotide (NMN), and nicotinic acid (NA).
• Data analysis and interpretations. We compare the obtained NAD⁺ levels to reference ranges or established standards, identifying trends or patterns, and providing insights into the potential implications for aging or age-related diseases.

At CD BioSciences, our team comprises eminent scientists and researchers, ensuring unparalleled expertise in aging biology and NAD⁺ analysis. Understanding the diverse facets of aging biology, we offer tailored solutions to adeptly address the unique requirements of our clients. If you are interested in our services, please feel free to contact us or make an online inquiry.

Reference

1. Bhasin S, et al. Nicotinamide Adenine Dinucleotide in Aging Biology: Potential Applications and Many Unknowns. Endocr Rev, 2023, 44 (6), 1047-1073.