Aging is a biological process that occurs universally and results in a gradual and irreversible decline in physical function across all organ systems. This decline is caused by the accumulation of damage in response to various stressors. Currently, some reports summarize aging in different organisms, particularly mammals, into nine common features. These features include genomic instability, telomere depletion, epigenetic alterations, loss of proteostasis, dysregulation of nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication.
Fig. 1 Hallmarks of aging. (Guo J, et al., 2022)
The aging process encompasses changes at the molecular, cellular, and organismal levels that can be analyzed by a variety of methods. CD BioSciences can provide a comprehensive analysis of these alterations in aging using an interdisciplinary approach, advanced technologies, and a team of senior experts with many years of experience.
CD BioSciences performs molecular-level aging analysis services that typically involve advanced techniques to analyze cellular and molecular components associated with aging. Our genomic instability analysis involves the assessment of DNA damage and repair processes, while telomere dysfunction evaluation focuses on the critical role of telomeres in cellular aging and replicative senescence. Additionally, we meticulously examine epigenetic alterations, such as changes in DNA methylation patterns and histone modifications, which can have profound effects on gene expression and aging-related processes.
Our services also encompass the analysis of loss of protein homeostasis, which involves studying the regulation of protein synthesis, folding, and degradation within cells. We provide the assessment of impaired autophagy, a vital process for cellular waste removal and recycling, which allows for a comprehensive understanding of its impact on aging and age-related diseases. Furthermore, our experts delve into mitochondrial dysfunction, exploring the role of these crucial cellular organelles in energy production, oxidative stress, and aging-related processes.
CD BioSciences offers comprehensive cellular-level aging analysis services to decipher the intricate changes occurring within individual cells. Our focus encompasses a detailed analysis of cellular senescence, shedding light on the mechanisms and implications of cells entering a senescent state as part of the aging process. Additionally, we delve into the analysis of stem cell depletion during aging, aiming to understand the impact of declining stem cell populations on tissue regeneration and repair processes. Moreover, our services include the analysis of altered intercellular communication, examining changes in signaling pathways and communication mechanisms between cells that contribute to age-related physiological changes.
CD BioSciences conducts a comprehensive systemic analysis to uncover the multifaceted alterations associated with aging. We perform an in-depth analysis of inflammaging and its impact on age-related diseases. Additionally, our services include the analysis of nutrient-sensing disorders during aging, with a focus on the dysregulation of metabolic pathways and their influence on the aging process. Furthermore, we investigate gut microbiota disorders and their relationship with age-related physiological changes. We also analyze neuroendocrine disorders and their broader physiological implications resulting from age-related changes in the endocrine system.
CD BioSciences offers unparalleled aging mechanisms analysis services that encompass molecular, cellular, and systemic levels of investigation. Through our advanced techniques and multidisciplinary approach, we strive to unravel the secrets of aging and contribute to the development of strategies for healthy aging and age-related disease intervention. If you are interested in our services, please feel free to contact us or make an online inquiry.
Reference
- Guo J, et al. Aging and aging-related diseases: from molecular mechanisms to interventions and treatments. Signal Transduct Target Ther. 2022, 7 (1): 391.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
