Planaria Model Customization Services for Aging Research

The planaria model is advantageous for the study of aging due to its size, tractable genetics, ease of maintenance, and ability to recapitulate the aging process. The regenerative capacity of planarians, together with shared senescence-associated genes with humans, provided the rationale for studying the interaction between stem cells and senescent cells in vivo. With our understanding of aging model systems, CD BioSciences is poised to empower clients' aging research efforts with customized planaria model solutions that can propel the investigations to new heights.

Fig. 1 Inducing aging in planarians using γ-ray irradiation. (Perrigue PM, et al., 2015)

Our Planaria Model Customization Options for Aging Research

Planaria species selection

We offer a comprehensive selection of planaria species, each with its unique characteristics and advantages. From the well-studied Schmidtea mediterranea to the lesser-known Dugesia japonica, our team of experts will work closely with clients to identify the optimal planaria species for their specific research objectives.

Induction of senescence in planarians

We employ several techniques to induce senescence in planaria models, such as exposing planarians to irradiation, oxidative stress, DNA-damaging agents, or other stimuli that trigger cellular senescence.

Phenotypic screening

We offer phenotypic screening services to identify and characterize age-related traits and phenotypes in planaria models, including but not limited to physical appearance, body mass, and size. Our comprehensive approach enables clients to understand the physiological changes associated with aging, facilitating the identification of potential interventions and therapeutic targets.

Imaging analysis services

CD BioSciences enables clients to conduct thorough imaging analyses of planaria models to observe and quantify age-related morphological and physiological changes. High-resolution imaging techniques provide detailed insights into the structural alterations and regenerative capacity of planaria, advancing the understanding of aging processes at the cellular and tissue levels.

Analysis of the Interaction Between Stem Cells and Senescent Cells in Planaria Models

Leveraging the inherent plasticity of these flatworms, our team of experts can delve deep into the mechanisms that govern the delicate balance between stem cell function and cellular senescence, uncovering the crucial role these processes play in the aging trajectory.

• Stem cell dynamics. Based on the regenerative capacity of planarians, our analysis services enable clients to closely monitor the behavior of stem cells throughout the aging process. We help clients track the proliferation, differentiation, and self-renewal of stem cell populations, shedding light on the mechanisms that govern their ability to maintain tissue homeostasis and repair.
• Cellular senescence. Through staining for senescence-associated beta-galactosidase (SA-β-gal) activity and analyzing senescence-associated secretory phenotype (SASP), our services uncover the cellular senescence in planarian models.
• Uncovering the crosstalk. Ultimately, our analysis services help clients reveal the intricate signaling pathways, metabolic changes, and epigenetic modifications that govern the balance of stem cell dynamics and cellular senescence.

At CD BioSciences, we are driven by a relentless pursuit of scientific excellence and a deep commitment to supporting our clients' groundbreaking aging research. We offer a suite of customized planaria model systems and complete analysis services that can propel your investigations to the forefront of the field. If you are interested in our services, please feel free to contact us or make an online inquiry.

Reference

1. Perrigue PM, et al. Planarians as a model of aging to study the interaction between stem cells and senescent cells in vivo. Pathobiol Aging Age Relat Dis, 2015, 5: 30052.