Characterization of Age-Related Physical Performance in Animal Models

Physical performance is a crucial aspect of aging evaluation, as it determines an animal's ability to perform daily activities and respond to environmental demands. As animals age, their physical performance declines due to various physiological changes, such as reduced muscle mass, decreased muscle function, and altered locomotion patterns. Assessing these changes is important for understanding the mechanisms of aging and developing interventions to promote healthy aging.

As a trusted research service provider specializing in characterizing age-related physical performance, CD BioSciences is committed to delivering advanced equipment, detailed protocols, and reliable experimental data to support our clients' research objectives.

Characterization of Neurological Function in Aging

We offer hindlimb clasping test services to allow our clients to assess neurological function and detect potential signs of age-related decline. Our test measures an animal's response to a stimulus, such as tail suspension, which typically results in the clasping of the hindlimbs. Abnormal responses can indicate neurological deficits associated with aging. We provide detailed summaries of the observed hindlimb clasping behavior, including the onset, severity, and duration of the phenotype. Additionally, using advanced sequencing techniques, we assist clients in identifying the specific genes, signaling pathways, and molecular networks that are significantly expressed in association with the phenotype of the hindlimb clasping behavior.

Characterization of Muscle Strength in Aging

We offer vertical and horizontal grid test services using customized equipment and rigorous data collection methods. Animals of different age groups are placed on an inverted wire mesh grid, which is then slowly turned upside down. We record parameters such as the fall latency, average step distance, hang time, and percentage of wall time to evaluate their muscular strength. We help clients uncover subtle age-related changes in motor function.

Characterization of Muscular Function in Aging

Grip strength is a widely accepted indicator of muscular force and health in aging models. Our experts gently lift the tested animal by the tail and allow it to grasp a steel grip bar with its forepaws or hindpaws. The animal is then pulled horizontally until it releases the grip, and the force required to do so is recorded. We offer comprehensive assessments including forelimb, hindlimb, bimanual grip strength, and endurance-based grip tests using calibrated grip strength meters.

Characterization of Endurance in Aging

The wire hanging test is a classic assay used to assess muscular strength and endurance in animal models. Our wire hanging test services are tailored to meet the specific needs of aging research. We help clients customize a suspended stainless-steel wire grid over soft paper chip bedding. During the test, we place the animals at the center of a top lid with a wire grid. We leverage video tracking technology to capture and analyze animal performance on the wire grid.

At CD BioSciences, our physical performance analysis services are integral to aging research, providing crucial insights into age-related functional decline. Our services are essential for understanding the impact of aging on neurological and muscular systems and for developing anti-aging drugs to enhance healthy aging. If you are interested in our services, please feel free to contact us or make an online inquiry.

Reference

1. Ana PV and Fariñas I. Behavioral evaluation of aging in experimental animals. Assessments, Treatments, and Modeling in Aging and Neurological Disease, 2021, 553-564.