Aging is associated with a decline in motor coordination, potentially affecting balance, gait, and overall physical performance. This decline increases the risk of falls and injuries in the elderly. Motor behavior mainly measures the autonomous activity of animals without environmental interference, which is one of the most basic behavioral performances of animals.
Fig. 1 A selection of behavioral tests for animal models. (Brooks SP and Dunnett SB, 2009)
CD BioSciences offers a range of services to characterize aging-related changes in motor function. Our team of experts is highly skilled in conducting motor behavior tests, ensuring the consistent and reliable data collection.
Characterization of Aging-Related Motor Function Using Rotarod Tests
The rotarod test is a well-established method for evaluating balance, coordination, and motor learning abilities in animal models, all of which can be affected by aging. We offer comprehensive standard and accelerated rotarod testing protocols tailored to the specific needs of aging research. We measure the latency to fall from the rotating rod and the number of falls, allowing our clients to assess age-related declines in motor performance. Additionally, we also evaluate the efficacy of anti-aging therapeutics in mitigating motor dysfunction.
Characterization of Aging-Related Motor Function Using Pole Tests
CD BioSciences offers pole test services that evaluate an animal's ability to navigate a vertical pole, a task requiring coordination and motor planning. We measure the time it takes for the tested animals to descend a vertical pole and the number of errors or missteps they make during the task. We help clients reveal aging-related changes in motor control and coordination, accelerating the development of anti-aging drugs.
Characterization of Aging-Related Motor Function Using Beam Walking Tests
Beam walking tests are highly sensitive to motor impairments and are used in aging research. CD BioSciences provides beam walking test services to help clients assess gait and balance in animal models. Animals traverse a narrow beam, with customizable parameters such as beam width, length, and texture to suit different research objectives. We measure and record the parameters, such as hind leg foot slips (right and left), number of falls during the trial, and total number of steps, to help clients unveil age-related changes in motor function.
Characterization of Aging-Related Motor Function Using Wheel Running
We offer comprehensive wheel running analysis services to support clients in evaluating the physical, cognitive, and metabolic effects of aging in animal models. We measure parameters such as running speed, distance, and duration, as well as cognitive and metabolic indicators observed during voluntary wheel running. Our experienced team analyzes the data to reveal the impact of aging on exercise capacity, motivation, and related physiological processes.
At CD BioSciences, our motor behavior analysis services serve as robust tools for assessing the impact of aging on physical function. With expertise in rotarod, pole, beam walking, and voluntary wheel running tests, we enable clients to perform in-depth investigations into aging-related motor decline. If you are interested in our services, please feel free to contact us or make an online inquiry.
Reference
- Brooks SP, Dunnett SB. Tests to assess motor phenotype in mice: a user's guide. Nat Rev Neurosci, 2009,10 (7): 519-29.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
