Animal behavioral analysis is a crucial component of aging research and the development of anti-aging drugs. Age-related changes in animal behavior can manifest in various ways, including alterations in activity, social interactions, cognitive functions, and responses to stress. By understanding how aging affects behavior, researchers can better design and evaluate anti-aging drugs to improve longevity.
Fig. 1 Conceptual scheme of the factors associated with age. (Azam S, et al., 2021)
CD BioSciences offers a comprehensive range of behavior analysis services designed to evaluate various dimensions of aging in animal models, from cognitive functions to physical and social behaviors.
Cognitive decline is a hallmark of aging. Our team at CD BioSciences provides comprehensive assessments of learning, memory, and cognitive function in aging animal models using behavioral paradigms. We employ a diverse array of behavioral tests, including Morris water and Y maze navigation, novel object recognition, and fear conditioning, to evaluate age-related impairments in these domains. Our detailed behavioral analysis allows clients to understand the neurobiological mechanisms underlying cognitive aging.
Emotional regulation is critical to overall well-being and is often affected by aging. Our team of experts is dedicated to providing in-depth assessments of emotional behaviors in aging animal models. We employ widely accepted tests, such as the elevated plus-maze, open-field, and light-dark box, to assess age-related changes in anxiety-like behaviors. To evaluate depressive-like behaviors in animal models, we offer forced swim test services. Our comprehensive approach allows us to deliver valuable insights into age-related emotional dysregulation, supporting the development of anti-aging therapeutics.
Alterations in motor function are a common consequence of aging. We offer a diverse suite of behavioral assessments in animal models, including rotarod performance, pole test, beam walking, and wheel running analysis, to unveil age-related changes in coordination, balance, and locomotor activity. Each service is designed to characterize motor deficits and their association with aging.
Aging often leads to declines in strength, endurance, and muscular function. We evaluate these parameters using specialized assessments such as hindlimb clasping tests, grid walk analyses, grip strength measurements, and wire hanging analysis. Our services facilitate the development of anti-aging therapeutics to maintain physical capabilities in the elderly.
Social behaviors can be significantly affected by the aging process. We offer specialized services to assess the impact of aging on social behaviors in animal models. Our team utilizes automated tracking systems to quantify parameters such as social approach and interaction patterns. We also provide intruder-resident paradigm analysis services to delve deep into social dynamics. Our services help clients reveal the complex relationship between aging and social cognition.
Sensory perception, including vision, hearing, and smell, often changes with age. Our platform is equipped to comprehensively evaluate these age-related sensory deficits in animal models. We offer a range of specialized tests, such as visual cliff, acoustic startle response, and olfactory discrimination tasks, to assess the impact of aging on sensory function.
CD BioSciences is dedicated to providing our clients with comprehensive behavioral evaluation of aging in animal models. If you are interested in our services, please feel free to contact us or make an online inquiry.
Reference
- Ana PV and Fariñas I. Behavioral evaluation of aging in experimental animals. Assessments, Treatments, and Modeling in Aging and Neurological Disease, 2021, 553-564.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
