Analysis of Age-Related Changes in Mitochondrial Structure

INQUIRY

Mitochondria are dynamic organelles with intricate internal structures, including the inner and outer membranes, cristae, and matrix. As organisms age, several notable changes can occur in mitochondrial structures. These changes encompass alterations in mitochondrial size, shape, distribution, cristae organization, inner membrane integrity, and matrix density. Age-related changes can also affect the connections of mitochondria with other cellular components, such as the endoplasmic reticulum, through mitochondrial-associated membranes (MAMs). At CD BioScience, we are dedicated to understanding and analyzing these age-related changes in mitochondrial structure to assist in the study of aging and age-related diseases.

Our Analysis Services for Age-Related Mitochondrial Structural Changes

Analysis of Age-Related Changes in Mitochondrial Morphology

Our advanced microscopy techniques and image analysis tools allow for the detailed examination of mitochondrial morphology, including changes in size, aspect ratio, circularity, and distribution within aging cells. We analyze variations in mitochondrial size, including length, width, and volume. We also perform circularity measurements to assess the roundness or elongation of mitochondria.

We eventually provide our clients with comprehensive data analysis, including the assessment of mitochondrial morphological parameters and insightful interpretation of the findings to support their progression of aging research initiatives.

Analysis of Age-Related Changes in Mitochondrial Ultrastructure

Through transmission electron microscopy (TEM) and 3D electron tomography techniques, we can provide in-depth analyses of ultrastructural changes in aging mitochondria. Our service assesses mitochondrial ultrastructure that changes with aging, including the arrangement of cristae, inner and outer membranes, and matrix density.

Upon completion of the analysis, our clients receive a comprehensive report that includes high-resolution images, quantitative data on morphological parameters, and an in-depth analysis of age-related ultrastructural changes.

Analysis of Age-Related Changes in Mitochondrial-Associated Membranes

Our comprehensive analysis of MAMs during aging includes morphology studies, lipid composition, protein profiling, and assessments to discern age-related changes in MAM integrity and functions. Our services are characterized by a well-structured workflow that encompasses sample preparation, experimental execution, data acquisition, and in-depth data analysis.

We observe the morphology and spatial organization of MAM in the samples. We also perform mass spectrometry or protein profiling of the proteome of MAM. In addition, we extract lipids from MAM samples and perform liposome analysis using mass spectrometry (MS) techniques.

Our Advantages

Experienced team of experts. Our team of biological specialists possesses extensive experience in mitochondrial research and age-related studies. This expertise ensures the highest quality of analysis and interpretation of data, contributing to the robustness and reliability of our insights.
Advanced imaging technologies. We harness state-of-the-art microscopy and imaging platforms to capture high-resolution images and 3D reconstructions, allowing for detailed analysis of mitochondrial structures in cells.
Customized analysis solutions. We understand the unique nature of research projects and offer analysis solutions to meet the specific needs of our clients, providing personalized insights into age-related mitochondrial changes.

Analysis of age-related structural changes in mitochondria is imperative for unraveling the intricacies of at the cellular level and identifying potential therapeutic targets for age-related diseases. At CD BioScience, we take pride in our cutting-edge technologies and multidisciplinary approach to studying age-related changes in mitochondrial structures. If you are interested in our services, please feel free to contact us or make an online inquiry.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.