Aging is a multidimensional biological process that progresses at different rates across organs and tissues. Conventional measures of biological age often fail to capture these nuances, limiting their utility in disease prediction, therapeutic intervention, and biomarker discovery. Using high-throughput omics, advanced computational modeling, and precision biological tools, CD BioSciences provides a comprehensive suite of organ-specific biological clock development services to support the discovery and development of anti-aging drugs.
Organ-Specific Aging Clock Development Services
Brain Aging Clock Development Services
Using DNA methylation profiling, miRNA sequencing, single-cell transcriptomics, and cerebrospinal fluid proteomics, CD BioSciences helps clients develop brain aging clocks that reflect the biological age of brain regions. Our experts also use brain clocks to quantify discrepancies between brain age and chronological age, aiding in the study of aging-related neurodegenerative diseases and the development of anti-aging drugs.
Cardiac-Specific Epigenetic Clock Development Services
Our company supports clients in developing cardiac-specific epigenetic clocks using DNA methylation data derived from cardiomyocytes, endothelial cells, and cardiac fibroblasts. Our services include methylation sequencing, custom assay development, and customization of in vitro and in vivo cardiac aging models, enabling pharmaceutical clients to evaluate anti-fibrotic, senolytic, or metabolic therapeutics targeting cardiac-specific aging.
Gut Aging Clock Development Services
The gut is a dynamic organ where epithelial renewal, microbiota composition, and immune function shift dramatically with age. We assist clients in developing gut-specific aging clocks based on DNA methylation, transcriptome analysis, 16S rRNA microbiome profiling, and proteomic/metabolomic mapping. These tools help detect inflammatory conditions, microbial dysbiosis, and nutrient-processing impairments associated with gut aging.
Facial Aging Clock Development Services
Facial aging provides visible cues of biological aging and reflects underlying changes in the skin, subcutaneous tissue, and musculature. We provide a suite of services aimed at developing facial aging clocks to assess the biological age of facial tissues. Combined with in vitro and ex vivo skin models, our services support the evaluation of anti-aging skincare products and dermatological therapies.
Biomarker-Based Aging Clock Development Services
Lipid-Based Aging Clock Development Services
Lipidomic changes are a hallmark of tissue-specific aging, influencing cellular membrane integrity, oxidative stress, and inflammation. We offer lipid-based aging clock development services by quantifying thousands of lipid species from plasma, tissues, or single-cell extracts using high-resolution mass spectrometry platforms, such as LC-MS/MS and shotgun lipidomics. Our services are particularly valuable for assessing metabolic aging and adipose tissue degeneration.
Blood-Based Epigenetic Clock Development Services
Blood-based biomarkers provide non-invasive and scalable solutions for the estimation of biological age. Our company offers blood-based molecular clock development services integrating DNA methylation arrays, whole-genome bisulfite sequencing, plasma proteomics, metabolomics, and transcriptomics of circulating cells. These blood-based molecular clocks enable assessment of systemic aging processes, facilitate the early detection of aging-related diseases, including cardiovascular disease, metabolic syndromes, and cancers.
By focusing on the unique characteristics of each organ, CD BioSciences is dedicated to advancing the field of aging research. Our company is committed to delivering organ-specific biological clock development services integrated with multi-omic platforms and validated biological systems. If you are interested in our services, please feel free to contact us or make an online inquiry.
Reference
- Prattichizzo F, et al. Organ-specific biological clocks: Ageotyping for personalized anti-aging medicine. Ageing Res Rev, 2024, 96: 102253.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
