Analysis of Gut Microbiota Dysbiosis in Aging

The human digestive tract is inhabited by numerous microorganisms. The total estimated number of gut microorganisms is somewhere between 10¹³ and 10¹⁴, hovering around the total estimated number of human body cells (3-4×10¹³). With advancing chronological age, the gut microbiota becomes more diverse and variable. However, when measures of biological age are used with adjustment for chronological age, overall richness decreases, while a certain group of bacteria associated with frailty increases.

Fig. 1 Biological age-dependent gut dysbiosis and unhealthy aging. (Kim S and Jazwinski SM, 2018)

At CD BioSciences, we understand the importance of studying gut microbiota dysbiosis in aging to unravel its underlying mechanisms and identify potential therapeutic interventions. With our advanced analysis services, we provide comprehensive insights into the age-related alterations in gut microbiota composition, and function, and their implications in health and disease.

Overview of Our Gut Microbiota Dysbiosis Analysis Services

Age-stratified microbiome profiling

We offer microbiome profiling services that specifically stratify and compare gut microbiota composition across different age groups, allowing for the identification of age-related changes and dysbiosis patterns. We analyze fecal or intestinal samples obtained from individuals across different age groups, ranging from young adults to elderly individuals. By employing state-of-the-art sequencing technologies, such as 16S rRNA gene sequencing and metagenomics, we generate high-resolution profiles of the gut microbial communities.

Biomarker identification for age-related dysbiosis

We provide analysis services aimed at identifying specific microbial biomarkers or patterns associated with age-related dysbiosis, potentially linking these dysbiotic changes to age-related health outcomes. By comparing the gut microbiota profiles of healthy individuals across different age groups, we can identify specific microbial taxa or functional pathways that show consistent dysregulation with aging.

Microbiota-host interaction studies in age-related conditions

We offer analysis services to investigate the interactions between the gut microbiota and the aging host, focusing on age-related conditions such as frailty, cognitive decline, or immune senescence. We utilize in vitro and in vivo models, to investigate the functional consequences of age-related dysbiosis.

Longitudinal monitoring of gut microbiota in aging populations

We provide services for longitudinal monitoring of gut microbiota composition in aging individuals, allowing for the identification of temporal changes and their potential impact on age-related health trajectories. Our longitudinal approach allows clients to capture individual variations and temporal trends, providing valuable insights into the progression and stability of gut microbiota dysbiosis.

Our Workflow of Analyzing Gut Microbiota Dysbiosis in Aging

• Sample collection
  We assist in the collection and preservation of intestinal samples from individuals across different age groups.
• DNA extraction, sequencing, and bioinformatics analysis
  We perform high-quality DNA extraction from the collected samples and utilize sequencing technologies, such as 16S rRNA gene sequencing or metagenomics, to generate comprehensive gut microbiota profiles. Our expert bioinformaticians employ advanced algorithms and databases to analyze the sequencing data, including taxonomic profiling, diversity analysis, functional annotation, and biomarker identification.
• Data interpretation and reporting
  We provide detailed reports summarizing the findings of the analysis, including key microbial taxa, functional pathways, and potential biomarkers associated with age-related dysbiosis.

Why Choose Us?

• Specialized aging expertise. We have a deep understanding of the aging process, age-related diseases, and the interplay between gut microbiota dysbiosis and aging-related health conditions, enabling the development of targeted analysis services focusing on aging themes.
• Multi-omics integration capabilities. We are proficient in integrating microbiome data with other omics data (e.g., metabolomics, proteomics) to provide a comprehensive understanding of age-related dysbiosis and its functional implications.

CD BioSciences is dedicated to offering clients comprehensive services related to gut microbiota dysbiosis during the aging process, a complex and important area of research with significant implications for human health. If you are interested in our services, please feel free to contact us or make an online inquiry.

Reference

1. Kim S, Jazwinski SM. The Gut Microbiota and Healthy Aging: A Mini-Review. Gerontology. 2018, 64 (6): 513-520.