The aging process poses significant challenges to human health, with mitochondrial dysfunction emerging as a central hallmark of aging-related pathologies. Mitochondrial calcium ion dynamics have been implicated as crucial determinants of cellular function and have garnered significant attention as potential targets for therapeutic interventions.
Fig. 1 Mitochondrial calcium homeostasis. (Szabo L, et al. 2020)
CD BioSciences recognizes the critical need for sophisticated analytical tools to elucidate the role of mitochondrial calcium in aging. Our mitochondrial calcium ion detection services are tailored to empower researchers in unraveling the complexities of aging and age-related diseases.
Overview of Our Mitochondrial Calcium Ion Detection Services in Aging
| Items |
Service details |
| Mitochondrial calcium load testing |
We conduct high-quality assays to quantify the levels of calcium within the mitochondria, providing a direct measurement of the calcium load. Our testing offers valuable insights into how age-related changes in mitochondrial calcium load may impact overall cellular and physiological function. |
| Mitochondrial calcium handling efficiency |
Our tests assess the ability of mitochondria to handle calcium, shedding light on the role of reduced calcium handling in aging-related mitochondrial impairments. |
| Mitochondrial calcium flux assessment |
We measure the dynamic movement of calcium in and out of mitochondria, which is crucial for mitochondrial function and is known to change with age. |
| Mitochondrial calcium-related biomarker analysis |
We offer analysis of specific biomarkers related to mitochondrial calcium regulation, which can provide insights into aging-related processes and potential points. Our services pave the way for the identification of novel pathways and targets for interventions related to mitochondrial calcium regulation in aging. |
Technical Tools for Mitochondrial Calcium Ion Detection Services
CD BioSciences leverages a range of technology and advanced data analysis tools to deliver mitochondrial calcium ion detection services. Our mass spectrometry and fluorescence microscopy enable us to offer high-resolution measurements of calcium dynamics, setting a new standard in the field of mitochondrial research in aging.
- Mass spectrometry. We use mass spectrometry to enable high-precision quantification of mitochondrial calcium levels, which offers exceptional sensitivity and specificity, allowing for the precise measurement of calcium ions within mitochondria.
- Fluorescence microscopy. Our fluorescence microscopy facilitates the visualization and quantification of calcium ion dynamics within live cells. Our service is based on the use of fluorescent proteins and dyes to monitor mitochondrial calcium. Among them, Rhod-2, AM, is a derivative of Rhodamine 123, which binds to calcium ions to produce fluorescence. Our imaging technology provides detailed insights into the spatial and temporal aspects of mitochondrial calcium regulation, offering valuable data for understanding aging-related changes in calcium handling.
- Advanced data analysis tools. CD BioSciences utilizes reliable data analysis tools and computational models to process and interpret complex datasets generated from mitochondrial calcium ion detection assays. Our tools enable the extraction of meaningful insights and the identification of age-related trends in mitochondrial calcium dynamics.
With decades of experience in the industry, CD BioSciences boasts a team of seasoned experts in the field of mitochondrial research in aging. We continuously invest in advanced instrumentation and methodologies to ensure the reliability of our mitochondrial calcium ion detection services. If you are interested in our services, please feel free to contact us or make an online inquiry.
Reference
- Modesti L, et al. Mitochondrial Ca2+ Signaling in Health, Disease and Therapy. Cells, 2021, 10 (6), 1317.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
