Telomere length shortening is associated with many biological processes in the body, including human aging and many related diseases. It can also change depending on external factors, so we need methods that can accurately quantify telomere length to investigate telomere-related findings in depth.
Average telomere length is one of the most studied telomere parameters. The average telomere length may vary in different organs, tissues, and cells in different individuals, and their differences may explain the mechanisms of specific cellular functions, as well as serve as individual characteristics that are biomarkers of aging, disease, and death. CD BioSciences can provide services to measure the average telomere length to explore telomere variation and dynamics in different individuals, tissues, and cells.
Overview of Our Average Telomere Length Measurement Services
We provide a variety of methods for measuring average telomere length so that researchers can choose the best option for their needs of aging research. In addition, we also provide the following related services:
- We conduct validation studies of the measurement method to ensure the accuracy of the test.
- We provide data on specific biological control samples, as well as detailed explanatory reports.
- We take care to explain the associations reported in relation to telomere length based on a statistical analysis of the assay results.
Sample Requirements
Sample types
Blood, saliva, urine, plasma, serum, solid tissue, etc.
Species
Human. mouse, rats, and other non-human primates.
Our Techniques for Average Telomere Length Measurement
We completely and systematically assess objective factors such as the client's study objectives, sample type, and analysis time to select the most appropriate mean telomere length measurement method.
| Technologies |
Descriptions |
Advantages |
| Telomere restriction fragment (TRF) |
We determine telomere length by observing Southern blots or in-gel hybridization using telomeric DNA-specific probes. |
Comparable results |
| Quantitative fluorescent in situ hybridization (Q-FISH) |
We determine telomere length by assessing the mid-chromosome or interphase nucleus after hybridization/labeling with a fluorescent probe. |
Reliable and repeatable results |
| Primed in situ subtype of Q-FISH (PRINS) |
We use PRINS labels to detect telomeric sequences in situ on metaphase chromosomes or interphase nuclei by fluorescently labeled nucleotides and PCR with telomeric primers. We assess the intensity of the FISH signal as described for the probe-based Q-FISH approaches. |
Assessing telomere lengths in specific cell types |
| Flow-FISH |
We use the telomeric (CCCTAA)3 PNA probe to quantify the mean amount of fluorescence present in cells. This value is then used to provide an average telomere length for the cell population being evaluated. |
Determining mean "length" for specific cell populations |
Applications of Average Telomere Length Measurement in Aging Studies
Our telomere length measurement services can serve as a breakthrough in exploring the processes of aging and age-related diseases such as cancer, enriching our understanding of disease mechanisms.
We measure telomere length in specific tissues related to age-related diseases, including telomere length assessments in cardiovascular tissues for cardiovascular aging studies, neurons for neurodegenerative disease-related aging studies, and other relevant tissues.
Our Advantages
- Expertise and specialization. We possess expertise and experience in telomere length measurement specifically for aging research. We can provide tailored solutions to meet the specific needs of researchers focused on aging-related studies.
- Optional measuring program. We do not limit ourselves to one measurement method and offer our customers a choice of measurement procedures to suit different needs.
- Rigorous analytical reports. Our methods are subject to rigorous analytical validation and the data are processed through statistical analysis to ensure the reliability of the results.
As telomere length measurement methods continue to evolve, CD BioSciences would like to be your sincere partner in telomere research, helping you with relevant studies and applications. Our average telomere length measurement service can be selected and tailored exactly to your research plan based on expert team advice and experience in experimental design, which can help you obtain highly accurate results. If you are interested in our services, please feel free to contact us or make an online inquiry.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
