Multi-Omics Aging Clock Development Services

Biological age reveals the actual degree of aging of an individual's physical condition, and the biological age of aging can be predicted by various indices, including changes in DNA methylation, telomere length, transcriptomics, proteomics, and metabolomics. Most studies have considered the predictive performance of several of these individual biological clocks separately, but comprehensive analyses of multiple aging markers are lacking.

To better understand the molecular mechanisms of aging, CD BioSciences provides services to help our clients calculate multiple biological aging indicators and generate compound clocks for aging-related research such as mechanism exploration, influence factor investigation, and therapy development by integrating different biological clocks for comprehensive analysis and thus revealing aging mechanisms and their effects at several molecular levels.

Overview of Our Multi-Omics Aging Clock Services

CD BioSciences offers a comprehensive range of multi-omics aging clock development services. Our services integrate data from multiple omics layers, including genomics, transcriptomics, proteomics, and metabolomics, to develop accurate and reliable aging clocks. These clocks provide a quantitative measure of biological age and offer insights into the underlying molecular processes associated with aging. Our services include but are not limited to the following.

• We measure biological aging indicators at different molecular levels from DNA to metabolites, including DNA methylation, transcriptome, proteome, and metabolome clocks.
• We assess whether the composite biological clock is superior to a single bioindicator of aging in terms of its association with aging.
• We also analyze the relationship between comprehensive biological aging indicators and various physical, psychological, and external factors.

Workflow for Multi-Omics Aging Clock Services

• Design research program
  We define the research objectives with the client, set up a research team with a dedicated person in charge, discuss the specific experimental plan, and define and execute it according to the plan.
• Perform the experimental protocol
  We can provide or assist in a range of operational steps from sample collection, sample processing, metric measurement, statistical analysis, and clock construction to evaluation and validation.
• Submit research results
  We subject all data and results generated from the research process to our clients in a graphical format via a project closure report.

Applications of Multi-Omics Aging Clocks

Single biological clock studies do not comprehensively examine and explore aging and related diseases because they do not capture the complexity of the aging process. We provide research services that allow for a broad integrated analysis of multiple aging indicators that have the following applications.

Biological aging measurement

We assist our clients in developing multi-omics aging clocks that reliably forecast an individual's biological age, which is a better indicator of overall health and longevity compared to chronological age. This information can be used to assess an individual's risk for age-related diseases and guide personalized lifestyle interventions.

Aging mechanism research

We integrate the analysis of molecular data from different sources to improve our understanding of the mechanisms and effects of biological aging.

Drug discovery and development

We help our clients develop multi-omics aging clocks to aid in the discovery and development of novel therapeutics targeting age-related diseases. By identifying key molecular pathways and targets associated with aging, these clocks provide valuable insights for drug screening and personalized medicine approaches.

In this service, we elucidate the complex and multifactorial process of biological aging from a comprehensive perspective based on multiple biological clock levels. We can not only calculate a sensitive and accurate aging composite index by summarizing multiple biological aging indicators but also observe the determinants closely related to individual biological aging through it.

CD BioSciences strives to provide our clients with accurate and reliable multi-omics aging clocks to shed light on the molecular mechanisms of aging. If you are interested in our services, please feel free to contact us or make an online inquiry.

References

1. Jansen R, et al. An integrative study of five biological clocks in somatic and mental health. eLife Sciences, 2020.
2. Kothari M and Belsky D W. Aging: Unite to predict. eLife Sciences, 2021, 10.