Mitochondria are a crucial organelle for generating and regulating cellular bioenergetics, which supply energy in the form of ATP through the oxidative phosphorylation system (OXPHOS). Several studies have indicated that there is a decline in mitochondrial oxidative phosphorylation efficiency with increasing age, often accompanied by an increase in the production of reactive oxygen species (ROS) and oxidative damage to mitochondrial components. These factors can lead to functional changes in mitochondria, impacting cellular energy production and potentially contributing to age-related pathologies.
Fig. 1 Schematic representation of OXPHOS in mitochondria. (Szabo L, et al. 2020)
At CD BioSciences, our mitochondrial OXPHOS analysis services are tailored to meet the specific needs of aging research. We understand the critical role of mitochondrial function in the aging process and are committed to providing unparalleled expertise and technology to support research efforts in this field.
Overview of Our Mitochondrial Oxidative Phosphorylation Analysis Services
Comparative OXPHOS analysis
Our comparative OXPHOS analysis services allow for the comprehensive assessment of OXPHOS efficiency in mitochondria from young and aged tissue/cell samples. Through advanced techniques, such as measuring oxidative phosphorylation enzyme activities and quantifying ATP production, we can provide valuable insights into the age-related alterations in mitochondrial bioenergetics. Our services enable clients to elucidate the specific aspects of OXPHOS that contribute to the aging process and identify potential targets for intervention.
| Service items |
Service descriptions |
| OXPHOS enzyme activity measurements |
We offer biochemical methods for the measurement of OXPHOS enzyme activity in aging. By quantifying the activity of each complex, our clients can discern specific changes that occur with age, such as the decline in enzyme activity linked to reduced mitochondrial function. |
| ATP production quantification |
We employ reliable methodologies for the quantification of ATP production in aging tissues and cells. By measuring ATP levels and evaluating ATP production rates, our clients can gain a comprehensive understanding of the energetic changes that occur with age. Our data is instrumental in elucidating the relationship between OXPHOS efficiency, ATP production, and the aging process, as well as in identifying potential targets for therapeutic intervention. |
OXPHOS dysfunction evaluation
We offer OXPHOS dysfunction evaluation services aimed at identifying and quantifying age-related changes in OXPHOS functionality. Our in-depth analysis is instrumental in understanding the mechanisms underlying age-related mitochondrial impairment and can inform the development of novel therapeutic strategies to mitigate age-related dysfunction.
Deliverables of Mitochondrial Oxidative Phosphorylation Analysis
We provide mitochondrial OXPHOS analysis services to deliver actionable insights and tangible outcomes for aging research. Our advanced capabilities and expertise enable us to provide a range of deliverables that empower researchers in their quest to unravel the complexities of mitochondrial function in aging.
- We provide high-resolution data and graphical representations of enzyme activities for complexes I, II, III, IV, and V, enabling fine-grained analysis of their alterations in aging.
- We offer quantification of ATP production rates, offering insights into the capacity of mitochondria to generate cellular energy and the impact of aging on this critical process.
CD BioSciences is dedicated to advancing the frontiers of aging research through our comprehensive mitochondrial OXPHOS analysis services. Our expertise, advanced technologies, and deliverables empower clients to make meaningful strides in understanding and addressing the complex interplay between mitochondrial OXPHOS and aging. If you are interested in our services, please feel free to contact us or make an online inquiry.
Reference
- Szabo L, et al. Insights into Disease-Associated Tau Impact on Mitochondria. Int J Mol Sci, 2020, 21 (17), 6344.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
