Aging-Related Bone Disease Research and Drug Development

Pathogenic Mechanism Analysis Services for Aging-Related Bone Diseases

Our team of highly skilled researchers and scientists at CD BioSciences employs techniques to investigate the pathogenesis of aging-related diseases. By utilizing advanced molecular and cellular approaches, we aim to unravel the intricate interplay of factors contributing to bone loss, cartilage degradation, and joint inflammation.

• Analysis of cellular senescence. We investigate the senescent cell burden, senescence-associated secretory phenotype (SASP), and the impact of senescent cells on the bone microenvironment. Through the use of senescence-specific markers and functional assays, we assess the presence and characteristics of senescent cells in bone tissues and cell cultures.
• Analysis of hormonal changes. We employ hormone profiling techniques, such as ELISA and mass spectrometry, to assess the levels of key hormones involved in bone metabolism. By analyzing hormone receptor expression, signaling pathways, and downstream effects, we gain insights into the molecular mechanisms underlying the hormonal regulation of bone remodeling, mineralization, and homeostasis.
• Analysis of metabolic dysregulation. Through biochemical assays and metabolic profiling techniques, we assess key metabolic markers, such as glucose metabolism, lipid profiles, and adipokine levels. By examining the cross-talk between metabolic pathways and bone cells, we gain insights into the molecular mechanisms underlying the interplay between metabolic dysregulation and bone diseases associated with aging.