Age-Related Immune Dysfunction Research and Drug Development Services

Age-Related Immune Dysfunction Research and Drug Development Services

Human aging is characterized by both physical and physiological frailty that profoundly affects the immune system. In this context, aging is associated with declines in adaptive and innate immunity established as immunosenescence. Immunosenescence is a new concept that reflects the age-associated restructuring changes of innate and adaptive immune functions. Thus elderly individuals usually present chronic low-level inflammation, higher infection rates, and chronic diseases.

Aging of the immune system: mechanisms and therapeutic strategies.Fig. 1 Aging of the immune system: mechanisms and therapeutic strategies. (Cisneros B, et al. 2022)

With many years of experience in the industry, our team of skilled biological experts at CD BioSciences is dedicated to providing comprehensive research and development (R&D) services to address the challenges posed by age-related immune dysfunction.

Disease Types Pathogenesis Analysis Biomarker Identification Disease Model Customization Drug Discovery and Development

Pathogenic Mechanism Analysis Services for Age-Related Immune Dysfunction

CD BioSciences offers comprehensive pathogenic mechanism analysis services to investigate aging changes and unravel the complex interplay between aging and immune function.

  • Analysis of aging changes in innate immunity. Aging leads to alterations in innate immune responses, compromising their effectiveness. At CD BioSciences, we employ reliable techniques to analyze the aging changes in innate immunity, including the dysfunction of phagocytic cells and altered cytokine production. We utilize advanced flow cytometry and microscopy techniques to assess phagocytic activity, phagosome maturation, and intracellular killing ability of phagocytic cells in the context of aging. By characterizing the cytokine profiles, we assist clients in gaining insights into the age-related alterations in immune signaling and identify potential targets for modulating immune responses.
  • Analysis of aging changes in acquired immunity. Aging significantly impacts the functionality of acquired immune cells, such as T and B lymphocytes. CD BioSciences offers comprehensive analysis services to investigate the aging changes in acquired immunity, including the decline in T cell diversity, impaired antibody responses, and alterations in memory cell function. We evaluated the changes in T cell subsets, cytokine production, and T cell receptor (TCR) repertoire to help clients understand age-related alterations in T cell-mediated immune responses. Additionally, our analysis includes phenotypic profiling of B cell subsets, assessment of antibody production, and evaluation of B cell receptor (BCR) diversity.

Biomarker Identification Services for Age-Related Immune Dysfunction

We provide specialized biomarker identification services to identify and validate biomarkers associated with age-related immune dysfunction. Our team employs advanced technologies and bioinformatics analysis to identify molecular signatures, genetic markers, and immune cell profiles that correlate with immune dysfunction in aging samples. By identifying reliable biomarkers, we facilitate early detection, treatment strategies, and monitoring of age-related immune dysfunction.

Disease Model Customization Services for Age-Related Immune Dysfunction

CD BioSciences offers disease model customization services. Our team specializes in developing and customizing preclinical disease models that accurately mimic the immune dysfunction observed in aging individuals. These models enable the investigation of underlying mechanisms, evaluation of therapeutic interventions, and assessment of drug efficacy.

We provide services to customize animal models by incorporating specific genetic modifications, such as knockouts or transgenic models, to target genes or pathways of interest associated with immune dysfunction. We also offer services to customize cell culture models by utilizing primary cells or cell lines derived from aged individuals. These cells can be characterized by their immune phenotype, functionality, and response to various stimuli. By using appropriate cells, researchers can study the impact of aging on immune cell behavior and identify potential therapeutic targets.

Drug Discovery and Development Services for Age-Related Immune Dysfunction

We offer a range of services aimed at accelerating the discovery and development of drugs targeting age-related immune dysfunction. Our comprehensive services encompass target identification, optimization, in vitro and in vivo efficacy studies, and pharmacokinetic and toxicological assessments. We offer absorption, distribution, metabolism, and excretion (ADME) profiling services, including in vitro assays and prediction models, to assess the drug candidates' ADME capacities. Utilizing disease models and customized experimental systems, our team assesses the impact of the drug candidates on immune cell function, inflammatory responses, and overall immune health.

At CD BioSciences, we are committed to advancing the understanding of age-related immune dysfunction and developing innovative therapeutic strategies, offering a diverse array of R&D services aimed at enhancing the quality of life for the elderly. If you are interested in our services, please feel free to contact us or make an online inquiry.


  1. Cisneros B, et al. Immune system modulation in aging: Molecular mechanisms and therapeutic targets. Front Immunol, 2022, 13: 1059173.
  2. Fuentes E, et al. Immune System Dysfunction in the Elderly. An Acad Bras Cienc, 2017, 89 (1): 285-299.
  3. Castle SC. Clinical relevance of age-related immune dysfunction. Clin Infect Dis, 2020, 31 (2): 578-85.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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