Human aging is characterized by both physical and physiological frailty that profoundly affects the immune system. In this context, aging is associated with declines in adaptive and innate immunity established as immunosenescence. Immunosenescence is a new concept that reflects the age-associated restructuring changes of innate and adaptive immune functions. Thus elderly individuals usually present chronic low-level inflammation, higher infection rates, and chronic diseases.
Fig. 1 Aging of the immune system: mechanisms and therapeutic strategies. (Cisneros B, et al. 2022)
With many years of experience in the industry, our team of skilled biological experts at CD BioSciences is dedicated to providing comprehensive research and development (R&D) services to address the challenges posed by age-related immune dysfunction.
Our team helps clients conduct in-depth analysis and characterization of inflammatory responses in aging individuals, aiming to identify key molecular targets and pathways involved in age-related inflammation.
We provide specialized R&D services to investigate the immune responses and vulnerabilities associated with age-related infectious diseases.
Based on the underlying mechanisms, we aim to identify novel therapeutic targets and develop innovative treatment approaches to mitigate the impact of age-related immune dysfunction on chronic disease development and progression.
Our team conducts detailed investigations into the immune mechanisms underlying age-related allergic responses, aiming to identify key mediators and develop targeted interventions.
CD BioSciences offers comprehensive pathogenic mechanism analysis services to investigate aging changes and unravel the complex interplay between aging and immune function.
We provide specialized biomarker identification services to identify and validate biomarkers associated with age-related immune dysfunction. Our team employs advanced technologies and bioinformatics analysis to identify molecular signatures, genetic markers, and immune cell profiles that correlate with immune dysfunction in aging samples. By identifying reliable biomarkers, we facilitate early detection, treatment strategies, and monitoring of age-related immune dysfunction.
CD BioSciences offers disease model customization services. Our team specializes in developing and customizing preclinical disease models that accurately mimic the immune dysfunction observed in aging individuals. These models enable the investigation of underlying mechanisms, evaluation of therapeutic interventions, and assessment of drug efficacy.
We provide services to customize animal models by incorporating specific genetic modifications, such as knockouts or transgenic models, to target genes or pathways of interest associated with immune dysfunction. We also offer services to customize cell culture models by utilizing primary cells or cell lines derived from aged individuals. These cells can be characterized by their immune phenotype, functionality, and response to various stimuli. By using appropriate cells, researchers can study the impact of aging on immune cell behavior and identify potential therapeutic targets.
We offer a range of services aimed at accelerating the discovery and development of drugs targeting age-related immune dysfunction. Our comprehensive services encompass target identification, optimization, in vitro and in vivo efficacy studies, and pharmacokinetic and toxicological assessments. We offer absorption, distribution, metabolism, and excretion (ADME) profiling services, including in vitro assays and prediction models, to assess the drug candidates' ADME capacities. Utilizing disease models and customized experimental systems, our team assesses the impact of the drug candidates on immune cell function, inflammatory responses, and overall immune health.
At CD BioSciences, we are committed to advancing the understanding of age-related immune dysfunction and developing innovative therapeutic strategies, offering a diverse array of R&D services aimed at enhancing the quality of life for the elderly. If you are interested in our services, please feel free to contact us or make an online inquiry.
References
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
CD BioScience is a contract research organization focused on aging research, specializing in providing research on aging mechanisms, preclinical drug discovery and development, and the development of healthcare and skincare products.
Copyright © 2024 CD BioSciences. All rights reserved.