Mitochondria play a pivotal role in cellular energy production and are essential for maintaining cellular homeostasis. As individuals age, the functional aspects of mitochondria undergo a series of alterations. These age-related changes in mitochondrial functions have been the subject of extensive research due to their implications for aging and age-related diseases.
Fig. 1 Mitochondrial functions that appear altered in human aging. (Morales Rosales SL, et al., 2020)
At CD BioSciences, we understand the significance of analyzing age-related changes in mitochondrial functions. Our specialized analysis services are designed to provide comprehensive insights into the various aspects of mitochondrial functions in the aging process.
Our analysis services focus on assessing the respiratory capacity of mitochondria in aging individuals. By determining changes in respiratory rates and efficiencies, we can identify age-related alterations in mitochondrial respiration. Our services encompass the assessment of mitochondrial respiration in a diverse range of species, including mice, rats, and human cell lines. We specialize in examining the dynamics of mitochondrial respiration in different organs and tissues as undergo senescence, including but not limited to skeletal muscles, platelets, hearts, brains, kidneys, and livers.
Through advanced techniques, we can elucidate the impact of aging on mitochondrial oxidative phosphorylation. Our comparative oxidative phosphorylation system (OXPHOS) analysis services allow for the comprehensive assessment of OXPHOS efficiency in mitochondria from young and aged tissue samples. Additionally, we offer OXPHOS dysfunction evaluation services aimed at identifying and quantifying age-related changes in OXPHOS functionality.
With tetramethylrhodamine methyl ester (TMRM), JC-1, and Rhodamine 123, we offer comprehensive mitochondrial membrane potential analysis services to elucidate these complex biological mechanisms, providing valuable insights for aging-related studies. Our services are available for various cell lines, including but not limited to lymphocytes, hepatocytes, and skeletal muscle cells, derived from aging animal models or individuals.
CD BioSciences leverages a range of technology and advanced data analysis tools to deliver mitochondrial calcium ion detection services. Our specialized analysis services, such as mitochondrial calcium load testing, handling efficiency, flux assessment, and biomarker analysis, enable the detection and quantification of age-related changes in mitochondrial calcium ion levels, offering a comprehensive understanding of the impact of aging on mitochondrial calcium ions.
Our analysis services are dedicated to assessing the dynamics of mitochondrial permeability transition pores (MPTP) in aging mitochondria, shedding light on age-related alterations in MPTP regulation. After completing the analyses, our team of experienced researchers meticulously analyze the data and generate comprehensive reports highlighting key findings and insights.
We are dedicated to providing a wide range of mitochondrial autophagy analysis services tailored to the study of aging. We provide mitochondrial autophagy flux measurements, aging-related mitochondrial autophagy marker assays, and aging-related mitochondrial autophagy pathway analysis services.
At CD BioSciences, our expertise, state-of-the-art technologies, and commitment to excellence set us apart in offering reliable solutions for addressing the complexities of age-related changes in mitochondrial functions. If you are interested in our services, please feel free to contact us or make an online inquiry.
Reference
- Morales Rosales SL, et al. Mitochondrial Function in Aging. Springer, 2020.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
