The aging process is a complex phenomenon influenced by a myriad of genetic and environmental factors. Whole genome sequencing (WGS) is one of the innovative approaches to unraveling the mysteries of aging and its underlying mechanisms, which involves deciphering the complete set of an individual's DNA instructions. It provides valuable insights into the genetic factors influencing aging-related phenotypes, diseases, and potential avenues for intervention.
CD BioSciences employs the latest next-generation sequencing platforms to ensure accurate and high-throughput WGS sequencing. Our experts are well-versed in the intricacies of aging research and possess a deep understanding of genomic data analysis.
Overview of Our Whole Genome Sequencing Services
CD BioSciences employs state-of-the-art sequencing platforms and advanced bioinformatics tools to generate accurate and comprehensive WGS. Using this technology, we can provide DNA sequences from all coding and non-coding regions of an individual's genome and identify genetic variants such as single nucleotide polymorphisms (SNPs), insertions, deletions, and structural variants.
Discovery of novel variants in aging
We focus on revealing rare or novel genetic variants that may be associated with aging or age-related diseases by WGS techniques. This broadens the scope of genetic investigation and enhances the potential for discovering new genetic factors involved in aging.
Exploration of non-coding regions in aging
We provide the examination of the non-coding regions of the genome to unravel their regulatory functions in aging processes, which have gained increasing attention for their potential regulatory roles.
Longitudinal studies in aging
We provide the comparison of an individual's genomic data at different time points, so our clients can assess genetic changes that occur with aging. This longitudinal perspective provides a dynamic view of the aging process and allows for the identification of genetic factors associated with age-related changes over time.
Our Workflow of Whole Genome Sequencing
From sample preparation, library preparation, DNA sequencing, and data quality control, to bioinformatics analysis, we provide high-quality and professional services. Each step is performed in agreement with a high scientific standard and meticulous design to ensure high-quality research results.
Fig. 1 Technical routes for whole genome sequencing.
- Sample collection and preparation. We provide detailed guidance on sample collection protocols. In addition, DNA extraction is continuously optimized to obtain high-quality pure DNA.
- Library preparation and sequencing. We employ cutting-edge library preparation methods to generate sequencing libraries. Then, next-generation sequencing technologies are utilized to sequence the entire genome.
- Data analysis. Our bioinformatics experts employ sophisticated algorithms to accurately map and align sequencing reads. Genetic variants, including SNPs, insertions, deletions, and structural variations, are identified and annotated.
WGS-Based Related Services
Comparative Analysis of Aging Genomes
CD BioSciences employs advanced computational methods to perform comparative genomic analysis, enabling the identification of conserved regions, evolutionary changes, and potentially novel genetic factors influencing the aging process.
Genome-Wide Association Study of Aging
We also conduct a genome-wide association study (GWAS) using state-of-the-art computational approaches and annotation tools to unravel the genetics behind aging-related traits and diseases. Using GWAS, we can identify genetic variants that link aging to age-related diseases such as cardiovascular disease, neurodegenerative diseases, and cancer.
CD BioSciences offers comprehensive whole genome sequencing services, along with comparative genomic analysis and genome-wide association studies, providing valuable insights into aging-related traits and diseases. If you are interested in our services, please feel free to contact us or make an online inquiry.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
