Aging-Related Liver Disease Research and Drug Development

Aging is associated with gradual changes in liver structure and function and various changes in liver cells, including hepatic sinusoidal endothelial cells. Aging can also increase the risk of various liver diseases and acts as an adverse prognostic factor leading to an increase in mortality. Drug development for aging-related liver diseases holds promise for improving outcomes and quality of life for elderly patients.

CD BioSciences provides preclinical contract research services specializing in aging-related liver disease research and drug development. With years of industry expertise, we are committed to providing high-quality and comprehensive research and development (R&D) services to advance our understanding of aging-related liver diseases and develop innovative therapeutic solutions.

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Our R&D Services by Type of Aging-Related Liver Diseases

At CD BioSciences, we recognize that aging-related liver diseases encompass a diverse range of conditions. We offer specialized R&D services tailored to each disease type, enabling a comprehensive and targeted approach to research and drug development.

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We offer a comprehensive range of R&D services to investigate NAFLD and develop potential therapeutic targets. Furthermore, we conduct drug development studies in animal models to identify these targets and perform preclinical research.

Non-alcoholic fatty liver disease (NAFLD)

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Our services include customizing disease models for preclinical studies of ALD, identifying the molecular pathways involved in disease progression, identifying potential therapeutic targets, and developing drugs.

Alcoholic liver disease (ALD)

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We offer specialized R&D services to help clients understand the mechanisms of liver fibrosis and develop effective anti-fibrotic therapies.

Liver fibrosis

Pathogenic Mechanism Analysis Services for Aging-Related Liver Diseases

Analysis of genomic instability. We employ genomic technologies to identify and characterize genomic instability in aging-related liver diseases. Whole-genome sequencing, targeted gene sequencing, and single-cell sequencing are utilized to analyze DNA alterations and identify genetic variants associated with disease susceptibility and progression. Through unraveling the genomic landscape, we aim to elucidate the genetic factors contributing to aging-related liver diseases and identify potential therapeutic targets.
Analysis of metabolic dysregulation. We offer comprehensive metabolic profiling services to identify alterations in metabolic pathways, identify dysregulated metabolites, and uncover metabolic signatures associated with aging-related liver diseases, facilitating a deeper understanding of disease mechanisms and potential therapeutic targets. Metabolomics analysis, using techniques such as liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS), allows for the identification and quantification of small molecules involved in metabolic pathways.
Analysis of mitochondrial dysfunction. We provide specialized analysis services to assess mitochondrial function and integrity. Techniques such as mitochondrial DNA (mtDNA) sequencing, measurement of mitochondrial respiration and membrane potential, and analysis of mitochondrial reactive oxygen species (ROS) production are employed to evaluate mitochondrial function in liver tissues and cells.

Biomarker Identification Services for Aging-Related Liver Diseases

We offer comprehensive biomarker identification services to facilitate the development of reliable diagnostic tools for aging-related liver diseases. Our expert team utilizes advanced techniques such as high-throughput screening, proteomics, and metabolomics to identify and validate potential biomarkers. We aim to discover novel biomarkers that can improve disease detection, predict disease progression, and monitor treatment response.

Disease Model Customization Services for Aging-Related Liver Diseases

CD BioSciences offers customized disease model customization services to meet specific research needs and accelerate drug discovery and development efforts. Our team has extensive experience in establishing in vitro cell culture systems and animal models that faithfully recapitulate the pathophysiological features of aging-related liver diseases.

Drug Discovery and Development Services for Aging-Related Liver Diseases

CD BioSciences is committed to driving the discovery and development of novel therapeutics for aging-related liver diseases. Our comprehensive drug discovery and development services encompass hit identification, optimization, and preclinical assessment. Using a multidisciplinary approach, we employ innovative screening platforms, medicinal chemistry strategies, and preclinical efficacy and safety assessments to identify and optimize potential therapeutic targets.

Healthcare R&D Services for Aging-Related Liver Diseases

Our company provides R&D services for healthcare products based on nutrients such as aspartic acid, ornithine, methionine, lycopene, and others to repair damaged and aged liver cells. Additionally, we offer animal models of aging-related liver diseases to evaluate the efficacy and safety of healthcare products. Our services also include conducting safety and toxicity studies to evaluate the potential adverse effects of healthcare products. We aim to improve healthy lifespan and prevent liver diseases associated with aging.

CD BioSciences is dedicated to advancing the understanding and treatment of aging-related liver diseases through our comprehensive range of R&D services. If you are interested in our services, please feel free to contact us or make an online inquiry.