Experimental Models

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All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

Organ-Specific Aging Model Customization Services

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Age-related changes in organ function are complex and vary across different tissues. These changes often involve a combination of intrinsic factors (genetic predisposition, cellular senescence) and extrinsic factors (environmental exposures, lifestyle choices). Accurate modeling of these processes requires sophisticated approaches that capture the unique characteristics of each organ system.

CD BioSciences offers organ-specific aging model customization services for preclinical drug discovery and development, enabling pharmaceutical companies to evaluate and optimize anti-aging therapeutics.

Skin aging models

Skin Aging Model Customization Services

CD BioSciences provides custom in vitro and in vivo models to study age-related skin changes. Our company offers custom human dermal fibroblasts and keratinocytes to mimic cellular senescence. We help clients customize bioengineered 3D skin models that integrate multiple cell types and a complex extracellular matrix. We also provide in vivo models, including mouse models of skin aging induced by D-galactose and UV irradiation, facilitating the study of age-related changes within a living organism.

Cardiac aging models

Cardiac Aging Model Customization Services

Our company offers custom cardiac aging models, which are critical for drug discovery and development in aging-related cardiovascular disease. We provide in vitro studies in senescent cardiomyocytes and in vivo studies in naturally aged mice and mouse models of accelerated aging to capture age-related changes in cardiac structure and function.

Aging liver models

Liver Aging Model Customization Services

We provide custom in vitro and in vivo models for age-related liver dysfunction research. We use primary hepatocytes to establish in vitro models by exposure to senescence-inducing agents or genetic manipulation. Our in vivo models encompass naturally aged animals, mimetic aging models, and transgenic models with genetic modifications impacting liver aging. All models are supported by thorough biochemical and histological characterization.

Lung aging models

Custom Models of Aging Lung

We offer custom lung aging models that reflect age-related changes. We provide aged lung epithelium to investigate the impacts of aging on pulmonary function and immune response. Additionally, we provide pulmonary fibrosis murine models with natural aging and senescence-accelerated mouse (SAM) models of the aging lung, facilitating the investigation of anti-aging therapeutics.

Models of aging kidney

Custom Models of Aging Kidney

We provide diverse custom models for studying age-related kidney decline. We provide renal tubular epithelial cells (RTECs) induced senescence through defined methods. Our in vivo models include naturally aged rodents, Klotho knockout (KO) mice, and canine models. Our company provides detailed assessments of renal function and characterization of age-related changes in kidney morphology.

Aging skeletal muscle models

Custom Models of Muscle Aging

Our company also offers custom models of muscle aging. We use both primary myocytes and immortalized cell lines to help clients construct in vitro models. Our in vivo models include naturally aged rodents, accelerated aging, genetically engineered mice, hindlimb unloading rodent models, etc. Our scientists help clients develop zebrafish models for high-throughput screening and real-time visualization of age-related changes.

At CD BioSciences, our comprehensive expertise in organ-specific aging models, combined with our commitment to customized solutions, ensures the development of reliable models that address your research needs. If you are interested in our services, please feel free to contact us contact us or make an online inquiry.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.