Aging is a multifaceted process characterized by the gradual decline of cellular functions, leading to an increased susceptibility to age-related diseases. Among the key cellular processes implicated in aging is autophagy, a highly regulated mechanism for degrading and recycling cellular components. Autophagy, particularly selective autophagy, plays a critical role in maintaining cellular homeostasis and supporting longevity by regulating the availability and turnover of intracellular macromolecules.
CD BioSciences is at the forefront of research and innovation in the field of biological sciences, with a particular focus on understanding the intricate mechanisms underlying aging. We provide services to evaluate selective autophagy pathways during aging, includingprotein homeostasis, glycophagy, lipophagy, RNAutophagy, and DNAutophagy. Our experts generate quantitative data on the degradation and turnover of corresponding macromolecular substrates in aging models, supporting objective assessment of how these selective autophagy processes change during aging.
Analysis of the Role of Autophagy in Protein Homeostasis During Aging
Autophagy declines with aging, contributing to impaired proteostasis and the accumulation of misfolded or aggregated proteins, including amyloid-β and tau, which are associated with neurodegenerative diseases such as Alzheimer's and Parkinson's disease. CD BioSciences provides services to assess autophagy-mediated protein quality control in aging models. Our service includes analysis of aggrephagy, expression profiling of longevity-associated proteostasis genes, evaluation of autophagy markers, and identification of selective autophagy substrates.
Analysis of the Role of Glycophagy in Aging
CD BioSciences provides services to analyze the role of glycogen in aging, supporting clients in investigating the impact of impaired glycophagy on cellular functions. Our assays enable quantitative evaluation of glycophagy activity in cells and tissues, as well as comprehensive analysis of glycogen metabolism, including glycogen synthesis, degradation, and mobilization.
Analysis of the Role of Lipophagy in Aging
CD BioSciences provides lipophagy analysis services to support the study of lipid turnover and selective lipid degradation in aging cells and tissues. Our assays enable the identification and quantification of lipid species, measurement of autophagic flux, monitoring of lipophagy-related proteins, and visualization of autophagic structures. We also offer services to assess age-related dysregulation by examining the expression of genes and proteins involved in lipophagy and lipid metabolism.
Analysis of the Role of RNAutophagy and DNAutophagy in Aging
CD BioSciences provides services to evaluate the regulatory mechanisms of RNAutophagy and DNAutophagy in aging cells and tissues. Our assays cover key selective nucleic acid clearance processes, including LC3-, p62-, and NDP52-dependent RNA degradation, as well as LAMP2C-dependent lysosomal uptake of nucleic acids and downstream degradation activity. Our services generate quantitative data on nucleic acid turnover and accumulation, supporting the assessment of their contribution to age-related cellular dysfunction.
Analysis of Selective Autophagy of Organelles in Aging
CD BioSciences provides analysis services for selective autophagy of organelles in aging cells and tissues. Our services cover mitophagy, ER-phagy, nucleophagy, and lysophagy, and include assessment of organelle turnover, autophagy flux, lysosomal activity, and related molecular markers. We integrate imaging, biochemical assays, and molecular biology techniques to generate quantitative data supporting research on age-related organelle dysfunction and therapeutic development.
CD BioSciences offers services for the analysis of autophagy regulation of macromolecule availability during aging. Through quantitative assessment of selective autophagy pathways and corresponding substrate turnover in aging models, we generate robust experimental datasets that support aging biology research and therapeutic development targeting proteostasis and macromolecular quality control. If you are interested in our services, please feel free to contact us or make an online inquiry.
Reference
- Aman Y, et al. Autophagy in healthy aging and disease. Nat Aging, 2021, 1 (8): 634-650.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
