As we age, the accumulation of reactive oxygen species (ROS) leads to oxidative stress, which is a significant contributor to aging and aging-related diseases. The elderly population is at increased risk for various age-related diseases, including neuropsychiatric disorders, tumors, and cardiovascular diseases. Selenium supplements are widely studied for their potential to support health in aging populations. Furthermore, the role of selenium in modulating immune responses can be beneficial in preventing infections and inflammatory diseases that are more prevalent in older adults.
Fig. 1 The key sources of selenium from food. (Payne A, et al., 2022)
CD BioSciences is committed to supporting our clients in the development of selenium supplements, with a primary focus on formulation development and comprehensive evaluation of anti-aging efficacy.
Our Selenium Supplement R&D Services
Formulation development services
Our company specializes in developing selenium supplements for anti-aging applications. We focus on selenium compounds such as selenomethionine and sodium selenite, which are known for their roles in reducing oxidative stress, maintaining genomic stability, and supporting longevity. Our experts help design formulations, including tablets, capsules, and liquid forms, with a strong emphasis on improving absorption in the elderly. We also help clients identify appropriate dosages and formulation strategies to support the evaluation of the anti-aging potential of selenium supplements.
Bioavailability and exposure evaluation
Our company provides bioavailability and exposure assessment services to support the development of selenium supplements intended for healthy aging applications. Our experts focus on evaluating selenium uptake and systemic exposure, helping to inform formulation optimization and dosage strategy. We also support the assessment of accumulation potential and tolerability, providing data to guide the development of selenium supplements suitable for long-term nutritional use.
Evaluation of Anti-Aging Effects of Selenium Supplements
At CD BioSciences, we provide comprehensive evaluation services to assess the anti-aging potential of selenium supplements.
Evaluation of the antioxidant efficacy of selenium supplements
Selenium is a key component of selenoproteins, such as glutathione peroxidases and thioredoxin reductases, which protect cells from oxidative damage. We offer services to evaluate the antioxidant capacity of selenium supplements, measuring their ability to reduce reactive oxygen species (ROS) and prevent lipid, protein, and DNA oxidation in aging models. We also investigate the specific pathways through which selenium supplements exert their antioxidant effects.
Evaluation of the role of selenium supplements in genomic stability
Selenium has been shown to enhance DNA repair pathways, helping preserve genomic integrity. We offer advanced assays, including comet assays and DNA repair activity measurements, to assess whether selenium supplements reduce DNA strand breaks and improve DNA repair efficiency. We also evaluate the impact of selenium supplements on genomic stability markers in different cell types.
Evaluation of the role of selenium supplements in telomere length
Telomere shortening is a hallmark of aging. Using quantitative PCR and Southern blotting, we provide assays to determine whether selenium supplements support telomere maintenance, thereby promoting cellular longevity and delaying replicative senescence.
Through rigorous research and innovative formulation development, CD BioSciences is committed to advancing selenium supplements targeting anti-aging mechanisms. If you are interested in our services, please feel free to contact us or make an online inquiry.
References
- Cai Z, et al. Selenium, aging, and aging-related diseases. Aging Clin Exp Res, 2019, 31 (8): 1035-1047.
- Bjørklund G, et al. Selenium: An Antioxidant with a Critical Role in Anti-Aging. Molecules, 2022, 27 (19): 6613.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
