Vitamin E, a fat-soluble antioxidant, plays a crucial role in maintaining cellular integrity and combating oxidative stress. It consists of a group of eight compounds, primarily tocopherols and tocotrienols. Free radicals are linked to the aging process and various chronic diseases. Research indicates that adequate vitamin E intake is associated with improved skin health, reduced inflammation, and enhanced immune function, all of which are vital for combating age-related decline.
Fig. 1 The mechanism of vitamin E-mediated low-density lipoprotein lipid peroxidation. (Rizvi S, et al., 2014)
Leveraging in-depth expertise in aging biology, CD BioSciences specializes in customized vitamin E supplement R&D services from synthesis to formulation, to support the development of effective anti-aging supplements.
Overview of Our Vitamin E Supplement R&D Services
Vitamin E synthesis and extraction services
We extract vitamin E from natural sources using cold pressing or organic solvents, preserving its anti-aging properties. We also offer chemical synthesis of specific tocopherol isomers in high yields using optimized condensation and purification processes.
Formulation development and stability testing services
Our company offers formulation development services with an emphasis on the formulation stability of vitamin E supplements. We conduct comprehensive stability testing under various environmental conditions to assess how formulations maintain their potency and efficacy. Additionally, we employ encapsulation techniques, such as liposomal formulations and microencapsulation, to improve formulation stability and support the delivery of active ingredients in supplement development.
How Do We Analyze the Role of Vitamin E Supplements in Aging and Chronic Inflammation?
At CD BioSciences, we employ a comprehensive, multi-level approach to investigate the role of vitamin E supplements in aging and aging-related inflammatory diseases. Our in vitro studies enable clients to evaluate whether vitamin E supplements affect cellular senescence, proliferation, and apoptosis.
We measure reactive oxygen species (ROS) levels and antioxidant enzyme activities (such as superoxide dismutase and catalase) in cell models treated with vitamin E supplements, revealing how vitamin E mitigates oxidative damage that accumulates during aging.
Furthermore, we use Western blotting and RT-PCR to determine how vitamin E modulates critical aging-related signaling pathways, such as Nrf2, NF-κB, and MAPK pathways. These pathways are pivotal in mediating inflammatory aging ("inflammaging") and oxidative stress, both of which contribute to age-related functional decline and chronic diseases.
At CD BioSciences, our integrated analysis provides detailed insights into how vitamin E supplements alleviate aging-related effects, supporting the development of effective anti-aging interventions targeting oxidative stress and inflammation. If you are interested in our services, please feel free to contact us or make an online inquiry.
Reference
- Rizvi S, et al. The role of vitamin E in human health and some diseases. Sultan Qaboos Univ Med J, 2014, 14 (2): e157-65.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
