The quest for effective anti-aging therapies has gained momentum as the global population ages. Phosphoinositide 3-kinase (PI3K) has emerged as a pivotal target in anti-aging drug discovery due to its critical role in cellular processes, including metabolism, growth, and survival. It is closely associated with cellular or molecular features, such as genome instability, telomere dysfunction, epigenetic alterations, and mitochondrial dysfunction.
Fig. 1 PI3K signaling regulatory network. (Liu Y, et al., 2023)
CD BioSciences provides anti-aging drug discovery services focused on the inhibition of the PI3K signaling pathway. We aim to collaborate closely with clients to develop anti-aging drugs that address multiple aspects of aging-related cellular dysfunction, enhance metabolic function, and mitigate age-related decline.
How Do We Develop Anti-Aging Drugs Targeting PI3K?
Target identification and validation
We begin our anti-aging drug discovery services with thorough PI3K target identification and validation. We utilize advanced genomic and proteomic techniques to confirm PI3K as a viable target for anti-aging interventions. We help clients assess the contribution of the PI3K pathway to cellular senescence, apoptosis, and metabolic regulation.
Drug screening and optimization
We offer drug screening services for small molecules and biologics that exhibit inhibitory effects. Our high-throughput screening capabilities enable us to assist clients in rapidly evaluating thousands of potential drug candidates for their ability to modulate the PI3K pathway. We provide lead optimization services to enhance the pharmacological properties of lead candidates. We provide services to analyze how changes in chemical structure affect biological activity, allowing our clients to refine drug candidates for greater efficacy and specificity.
Preclinical testing
We help clients conduct in vitro and in vivo studies to evaluate the efficacy and safety of lead candidates. We assess the pharmacodynamics and pharmacokinetics of lead candidates in cellular models. Using animal models, such as mice and rats, we can help evaluate the therapeutic effects and potential side effects. We also provide analyses of the mechanism of action of drug candidates using biochemical assays and downstream pathway analysis.
Targeting PI3K in Aging-Related Diseases
- Aging-related neurodegenerative diseases. For aging-related neurodegenerative diseases such as Alzheimer's and Parkinson's, we help clients develop anti-aging drugs targeting the PI3K pathway to offer a novel strategy for neuroprotection by modulating the apoptotic and survival pathways in neurons.
- Aging-related metabolic diseases. By targeting the PI3K pathway, we help clients develop anti-aging drugs to restore metabolic balance and improve the progression of type 2 diabetes and obesity.
- Aging-related cancers. CD BioSciences also assists clients in developing anti-aging drugs that target the PI3K pathway to potentially inhibit tumor growth by restoring normal cell death mechanisms.
The exploration of PI3K as a target for anti-aging drug discovery presents an opportunity for innovation in biomedicine. CD BioSciences is dedicated to advancing research in this area, helping clients develop innovative therapeutics that enhance healthspan and combat age-related diseases. If you are interested in our services, please feel free to contact us or make an online inquiry.
Reference
- Liu Y, et al. The regulatory role of PI3K in aging-related diseases. Ageing Res Rev, 2023, 88: 101963.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
