FOXO (Forkhead box O) proteins are a family of transcription factors that play critical roles in the regulation of various cellular processes, including metabolism, stress resistance, and apoptosis. Their ability to integrate signals from various pathways positions them as essential mediators of aging-related biological functions. In lower organisms, such as yeast, worms, and flies, FOXOs have been linked to extended lifespan by enhancing metabolic health. For example, the Caenorhabditis elegans FOXO homolog DAF-16 activation has been shown to promote longevity through the insulin/IGF-1 signaling pathway.
Fig. 1 DAF-16/FOXO integrates signals from different pathways to modulate aging and longevity. (Sun X, et al., 2017)
CD BioSciences is dedicated to leveraging our expertise to help clients develop innovative drug discovery targeting FOXOs. We offer customized research and development services to address the specific needs of our clients, ensuring that our anti-aging drug discovery services are reliable.
How Do We Support Anti-Aging Drug Development Targeting FOXOs?
Target identification and validation
Using advanced genomic and proteomic technologies, we analyze the expression levels of FOXOs in various aging models. We use bioinformatics tools to identify specific pathways associated with FOXO proteins. Our expert team helps clients conduct in-depth functional studies to understand the role of FOXOs in cellular processes and their impact on aging.
Drug screening and optimization
CD BioSciences uses high-throughput screening techniques to identify small molecules and biologics that modulate the FOXO signaling pathway, particularly in aging and aging-related diseases.
Preclinical testing
CD BioSciences provides various animal models to assess the impact of FOXOs on aging-related physiological changes. We help clients assess the effects of drugs on biomarkers of aging, providing vital data to support drug development. Our experts also assist clients in conducting comprehensive pharmacokinetic and toxicological studies to ensure that drug candidates are suitable for further development.
Targeting FOXOs in Aging-Related Neurodegenerative Diseases
CD BioSciences supports clients in developing anti-aging drugs targeting FOXOs for neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases. We offer animal models to help clients study the role of FOXO in aging and neuronal stress response. Our team provides research services to evaluate drug effects on neuronal health and function, specifically assessing gene expression changes linked to FOXO proteins and their downstream targets.
Targeting FOXOs in Aging-Related Metabolic Diseases
FOXOs are known to regulate glucose homeostasis and lipid metabolism, making them critical players in the pathology of aging-related metabolic diseases. We assist clients in investigating the interplay between insulin signaling and FOXOs to elucidate potential targets for the development of anti-aging drugs. CD BioSciences evaluates the therapeutic benefits of drug candidates by monitoring metabolic markers and physiological responses in aging animal models.
Targeting FOXOs represents a promising avenue for developing therapeutics that can significantly improve healthspan and mitigate age-related diseases. CD BioSciences offers comprehensive drug discovery services from target identification and drug screening to preclinical testing. If you are interested in our services, please feel free to contact us or make an online inquiry.
References
- Martins R, et al. Long live FOXO: unraveling the role of FOXO proteins in aging and longevity. Aging Cell, 2016, 15 (2): 196-207.
- Sun X, et al. DAF-16/FOXO Transcription Factor in Aging and Longevity. Front Pharmacol, 2017, 8: 548.
- Du S, Zheng H. Role of FoxO transcription factors in aging and age-related metabolic and neurodegenerative diseases. Cell Biosci, 2021, 11 (1): 188.
- Testai L, et al. Role of hydrogen sulfide in cardiovascular ageing. Pharmacol Res, 2020, 160: 105125.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
