As the world's population ages, the demand for anti-aging therapies has surged, increasing interest in drug safety assessment. Safety pharmacology for anti-aging drugs is a critical area focused on evaluating the potential adverse effects of these innovative therapies. Adverse effects can manifest in various systems, necessitating a comprehensive evaluation.
Fig. 1 Illustration of established and emerging parameters/techniques investigated in five important organ systems in safety pharmacology studies. (Hamdam J, et al., 2013)
At CD BioSciences, we offer a comprehensive suite of safety pharmacology services tailored to the unique needs of anti-aging drug development. Our services help clients determine whether anti-aging drugs are effective and safe.
The cardiovascular system is often one of the first areas affected by pharmacological agents. At CD BioSciences, our cardiovascular safety assessment includes comprehensive testing of anti-aging drug candidates for their effects on heart rate, rhythm, and blood pressure. Utilizing telemetry and echocardiographic techniques, we help clients monitor major cardiovascular parameters to ensure early detection of potential cardiotoxicity.
We offer central nervous system safety assessments including behavioral tests to evaluate potential neurotoxic effects. Our tests assess locomotor activity, anxiety-like behavior, and cognitive performance. By conducting these assessments, we help clients determine whether anti-aging drug candidates do not compromise neurological health.
Respiratory safety is essential for any drug intended for long-term use, especially those targeting aging-related diseases. CD BioSciences conducts thorough pulmonary function tests to evaluate the impact of anti-aging drugs on respiratory health. Our services include assessments of respiratory rate, tidal volume, and gas exchange efficiency. We also help clients determine how anti-aging drugs may affect smooth muscle tone and airway responsiveness.
Our gastrointestinal safety testing focuses on assessing the impact of anti-aging drugs on gastrointestinal motility and function. CD BioSciences employs a variety of in vivo models to observe changes in digestion and absorption rates, as well as potential side effects such as nausea or diarrhea. We also assist in evaluating potential adverse effects on the gut lining, which lead to ulcers or other complications. Our comprehensive evaluation clients determine whether anti-aging drugs maintain gastrointestinal integrity while delivering therapeutic effects.
CD BioSciences utilizes experimental models to evaluate the potential nephrotoxic effects of anti-aging drugs. We help clients analyze the effects of drug candidates on renal function, including glomerular filtration rate (GFR), renal blood flow, and urine output.
We offer safety pharmacology studies in appropriate animal models to assess the effects of anti-aging drug candidates on liver enzyme levels and overall hepatic health. We also monitor liver function tests (LFTs) such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) to detect any signs of liver damage.
At CD BioSciences, our comprehensive safety pharmacology services for anti-aging drug development are integral to the pursuit of safe and effective therapeutics. If you are interested in our services, please feel free to contact us or make an online inquiry.
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All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
CD BioScience is a research service provider focused on aging research, specializing in providing research on aging mechanisms, preclinical drug discovery and development, and the development of healthcare and skincare products.
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