The field of anti-aging research has gained significant momentum in recent years, with a growing demand for effective interventions that target aging mechanisms. Understanding pharmacokinetics (PK) and pharmacodynamics (PD) is central to developing anti-aging therapeutics. PK describes how a drug is absorbed, distributed, metabolized, and excreted in the body, while PD focuses on the biochemical and physiological effects of the drugs.
Fig. 1 Graphical representation of three commonly used PK-PD indices. (Labreche MJ, et al., 2015)
CD BioSciences offers a comprehensive range of PK/PD services to support the development of anti-aging drugs, helping clients understand the pharmacokinetic and pharmacodynamic behavior of drug candidates.
Our PK/PD Services for Anti-Aging Drug Development
In vitro PK services
Our company offers in vitro PK studies, including absorption, distribution, metabolism, and excretion (ADME) characteristics of anti-aging therapeutics. Using advanced assay platforms such as microsomal stability assays, plasma protein binding (PPB) studies, and Caco-2 permeability assays, we help evaluate metabolic stability, predict bioavailability, and assess potential drug-drug interactions.
In vivo PK services
Our in vivo PK services involve detailed pharmacokinetic evaluations in animal models. We perform blood and tissue sampling followed by bioanalytical quantification to determine key PK parameters such as area under the curve (AUC), maximum plasma concentration (Cmax), time to Cmax (Tmax), half-life, and clearance rates. Our services play a crucial role in optimizing formulation strategies and ensuring the safety and efficacy of anti-aging drug candidates.
In vitro PD services
We offer cell-based assays to evaluate the effects of anti-aging therapeutics at the molecular and cellular levels. Our services include assessments of senescence-associated β-galactosidase (SA-β-gal) activity, mitochondrial function, oxidative stress responses, and gene expression profiling. These in vitro analyses provide crucial insights into pharmacological activity before in vivo testing.
In vivo PD services
Our in vivo PD services focus on assessing the biological effects of anti-aging drugs in relevant animal models. Our studies are crucial for understanding how anti-aging drugs interact with their targets and the consequent physiological changes. We help clients conduct experiments to measure aging biomarkers, cellular senescence, and tissue regeneration, enabling our clients to evaluate the potential of anti-aging drug candidates.
PK/PD modeling
CD BioSciences provides advanced PK/PD modeling services that use computational tools to analyze the behavior of anti-aging drugs in various biological systems. Our modeling approaches allow for predicting anti-aging drug concentration over time and estimating dose-response relationships. We also specialize in both linear and non-linear PK modeling approaches. Linear models are used to analyze dose-proportionality and clearance, while non-linear models capture complexities such as saturable metabolism and target-mediated drug disposition (TMDD).
The evaluation of PK/PD is an indispensable component in developing safe and effective anti-aging drugs. At CD BioSciences, our PK/PD services are customized to meet the unique challenges of anti-aging drug development. If you are interested in our services, please feel free to contact us or make an online inquiry.
Reference
- Labreche MJ, et al. Recent Updates on the Role of Pharmacokinetics-pharmacodynamics in Antimicrobial Susceptibility Testing as Applied to Clinical Practice. Clin Infect Di., 2015, 61 (9): 1446-52.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
