Oxidative stress and inflammation progressively exert harmful effects, driving the onset of chronic diseases and accelerating the aging process. Lignans, a class of phytoestrogens found abundantly in seeds, grains, and certain vegetables, have garnered significant attention for their potential health benefits, particularly in the context of aging. These compounds exhibit antioxidant, anti-inflammatory, and estrogenic properties, crucial in mitigating age-related physiological changes and promoting overall health.
Fig. 1 Chemical structures of lignans and their metabolites. (Jang WY, et al., 2022)
At CD BioSciences, we provide specialized lignan supplement R&D services aimed at promoting healthy longevity. By combining advanced extraction, biosynthesis, formulation, and anti-aging efficacy evaluation, we help clients develop lignan supplements that target oxidative stress, inflammation, and cellular senescence.
Overview of Our Lignan Supplement R&D Services
Lignan isolation services
CD BioSciences uses advanced techniques such as solvent extraction, supercritical fluid extraction, and chromatographic methods to isolate lignans from plant materials. We also employ high-performance liquid chromatography (HPLC) and solid-phase extraction (SPE) to ensure the isolation of high-purity lignan for further anti-aging supplement development.
Lignan biosynthesis services
Our team specializes in metabolic engineering and synthetic biology to produce high-quality lignans. By leveraging genomic editing tools, we enable efficient, scalable biosynthesis of lignans to meet the increasing demand for supplements that support healthy aging and longevity.
Formulation development services
Our experts assist clients in developing formulations that enhance the bioavailability and stability of lignan supplements. Our expertise helps develop lignan supplement formulations with anti-aging benefits in delaying cellular senescence and promoting longevity.
Preclinical studies
We provide in vitro and in vivo aging models to support the evaluation of lignan supplements, focusing on their potential effects on aging-related processes. Our team also offers pharmacokinetic studies to characterize absorption, distribution, metabolism, and excretion, providing data to inform supplement formulation and anti-aging efficacy evaluation.
How Do We Evaluate the Anti-Aging Effects of Lignan Supplements?
In vitro studies
We use diverse cellular models to evaluate the effects of lignan supplements on aging-related markers, including oxidative stress, inflammation, and cellular senescence. By treating human skin fibroblasts and keratinocytes with lignan supplements, we measure changes in cell viability, proliferation, and the expression of senescence-associated markers.
In vivo studies
We administer lignan supplements to animal models of aging to assess their impact on physiological functions such as cognition, skin elasticity, and metabolic health. Through comprehensive evaluation, we also analyze changes in gene expression, protein regulation, and metabolic pathways in vivo, enabling our clients to determine how lignan supplements influence systemic aging processes.
At CD BioSciences, our comprehensive services, from lignan supplement formulation to anti-aging efficacy evaluation, are designed to support clients in the research and development of anti-aging supplements. If you are interested in our services, please feel free to contact us or make an online inquiry.
References
- Jang WY, et al. Antioxidant, Anti-Inflammatory, Anti-Menopausal, and Anti-Cancer Effects of Lignans and Their Metabolites. Int J Mol Sci, 2022, 23 (24): 15482.
- Su S, Wink M. Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans. Phytochemistry, 2015, 117: 340-350.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
