Luteolin, a potent flavonoid found in various fruits, vegetables, and herbs, has garnered significant attention in the health and wellness community due to its anti-inflammatory and antioxidant properties. The aging process is often characterized by increased oxidative stress and chronic low-grade inflammation, conditions that contribute to the development of age-related diseases. Luteolin's ability to scavenge free radicals and inhibit inflammatory pathways positions it as a promising candidate for supporting healthy aging.
Fig. 1 Structural formula of luteolin. (Gendrisch F, et al., 2021)
By focusing on formulation and anti-aging efficacy evaluation services, CD BioSciences supports the development of high-quality luteolin supplements that target key mechanisms of aging.
Overview of Our Luteolin Supplement R&D Services
Extraction, isolation, and identification of luteolin
CD BioSciences supports the development of luteolin supplements by extracting and isolating luteolin from natural sources, such as leaves and peanut hulls, to obtain high-quality active ingredients for supplement formulation. Our team employs advanced chromatographic techniques, including high-performance liquid chromatography (HPLC) and liquid chromatography–mass spectrometry (LC-MS), to confirm the identity, concentration, and quality of luteolin raw materials, providing data to support supplement development and subsequent anti-aging efficacy evaluation.
Luteolin biosynthesis services
Our company uses metabolic engineering and microbial fermentation to produce luteolin. We support clients in optimizing production strains and fermentation conditions to improve yield and batch-to-batch consistency. Our team offers anti-aging efficacy studies, including functional assays and pathway-related biomarker analyses, to assess its potential involvement in aging-related processes such as cellular metabolism and stress responses.
Formulation development services
Our formulation team supports the development of luteolin supplements in various forms, including capsules, tablets, powders, and liquids, with a focus on bioavailability and anti-aging efficacy. We also conduct rigorous stability studies to determine the shelf life of luteolin supplement formulations under different environmental conditions.
Evaluation of the Effects of Luteolin Supplements on Skin Aging
Skin aging is characterized by loss of elasticity, wrinkle formation, reduced barrier function, and dermal thinning, driven by intrinsic aging and extrinsic factors such as UV radiation. Our company supports clients in evaluating the anti-aging effects of luteolin supplements in skin aging models, focusing on its ability to reduce oxidative damage, inhibit matrix metalloproteinases (MMPs), and modulate collagen synthesis. We also evaluate the impact of luteolin supplements on aging-related signaling pathways, such as the AMP-activated protein kinase (AMPK) pathway, sirtuin signaling pathways, and the mammalian target of rapamycin (mTOR) pathway, which are closely associated with skin longevity and resilience.
Evaluation of the Effects of Luteolin Supplements on Inflammaging
Inflammaging refers to the chronic, low-grade inflammation that develops with aging, which contributes to the progression of aging-related diseases. Our experts offer detailed in vitro and in vivo studies using experimental models to investigate the effects of luteolin supplements on inflammaging. We help clients assess whether luteolin supplements modulate pro-inflammatory cytokine production and suppress key signaling pathways associated with aging, including nuclear factor Kappa B (NF-κB), activating protein-1 (AP-1), and Janus kinase-signal transducer and activator of transcription (JAK-STAT).
CD BioSciences is dedicated to offering luteolin supplement R&D services, driven by a commitment to quality and innovation. If you are interested in our services, please feel free to contact us or make an online inquiry.
References
- Gendrisch F, et al. Luteolin as a modulator of skin aging and inflammation. Biofactors, 2021, 47 (2): 170-180.
- Muruganathan N, et al. Recent Updates on Source, Biosynthesis, and Therapeutic Potential of Natural Flavonoid Luteolin: A Review. Metabolites, 2022, 12 (11): 1145.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
