Vitamin A acts as a powerful antioxidant, neutralizing free radicals that contribute to cellular aging. It is a vital nutrient in various biological functions, including vision, immune function, and cellular communication. As demand for health supplements continues to rise, the focus on the potential of vitamin A in promoting longevity and combating aging-related diseases has garnered significant attention.
Fig. 1 The structure of vitamin A and retinoids. (Carazo A, et al., 2021)
CD BioSciences offers a comprehensive suite of vitamin A supplement R&D services, combining rigorous analyses with innovative research strategies to support the development of anti-aging supplements.
Overview of Our Vitamin A Supplement R&D Services
Vitamin A synthesis and formulation development
CD BioSciences specializes in synthesizing high-purity vitamin A, including retinol and derivatives. We offer formulation development and stability testing services focusing on optimizing concentrations and delivery formats to improve anti-aging efficacy.
Anti-aging pharmacology services
Our company offers pharmacology services to investigate the molecular and cellular effects of vitamin A on key aging mechanisms. We provide in vitro and in vivo studies to evaluate whether vitamin A supplements modulate cellular senescence, reduce oxidative stress, and attenuate chronic inflammation, which are processes that contribute to tissue dysfunction and aging-related diseases.
Pharmacokinetic studies
We provide comprehensive pharmacokinetic studies using aging animal models to evaluate the absorption, distribution, metabolism, and excretion of vitamin A supplements. Our team supports dosing strategies of vitamin A supplements based on pharmacokinetic and safety assessments, facilitating evidence-informed formulation and administration decisions.
Evaluation of Vitamin A Supplements in Age-Related Macular Degeneration
Age-related macular degeneration (AMD) is a leading cause of vision loss in the elderly, making the role of vitamin A in eye health particularly significant. Utilizing cultured retinal pigment epithelium (RPE) cells, we assist clients in assessing the impact of vitamin A supplements on cell viability, proliferation, and gene expression, focusing on vital pathways implicated in AMD. Using animal models of AMD, we administer vitamin A supplements and monitor their effects on retinal integrity, functionality, and histology. We also simulate oxidative stress in cellular models and evaluate whether vitamin A supplementation reduces oxidative damage by measuring reactive oxygen species (ROS) levels and antioxidant enzyme activity (e.g., superoxide dismutase, catalase).
CD BioSciences is dedicated to providing vitamin A supplement R&D solutions ranging from synthesis to anti-aging pharmacology. If you are interested in our services, please feel free to contact us or make an online inquiry.
Reference
- Carazo A, et al.. Vitamin A Update: Forms, Sources, Kinetics, Detection, Function, Deficiency, Therapeutic Use, and Toxicity. Nutrients, 2021, 13 (5): 1703.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
