Characterizing metabolic pathways and identifying drug metabolites are essential steps in the development of safe and effective anti-aging drugs. Metabolites may possess biological activity or toxicity, thereby influencing drug efficacy and safety. Several studies have demonstrated that metabolite activity can differ significantly from that of the parent compound. Consequently, comprehensive metabolite profiling is essential to ensure regulatory compliance and achieve therapeutic success.
CD BioSciences uses advanced technologies and scientific expertise to provide specialized metabolite identification services, supporting pharmaceutical companies in accelerating the development of anti-aging drugs.
Sample Types
- In vitro samples: microsomal incubations, hepatocyte incubations, S9 fractions, etc.
- In vivo samples: Biological fluids such as tissue, plasma, urine, and bile collected from animal models or human.
Our Metabolite Identification Services for Anti-Aging Drug Development
Metabolic soft spot identification services
We offer metabolic soft spot identification services to characterize specific sites on anti-aging drug candidates that are susceptible to metabolic transformation. By identifying these metabolically labile regions, our experts help predict potential metabolic liabilities early in the development process. Using advanced analytical techniques such as NMR and mass spectrometry, we support the optimization of drug structures to enhance metabolic stability, improve therapeutic specificity, and minimize off-target effects.
Metabolite fingerprinting services
We offer metabolite fingerprinting for a comprehensive overview of the metabolic profiles of anti-aging drugs. We help clients unveil the metabolites produced to predict how anti-aging drugs may interact with other substances. We utilize sophisticated data mining and visualization software, enabling deeper insights into metabolic pathways and interaction mechanisms.
High-throughput reactive metabolite screening services
Our high-throughput screening services enable the rapid assessment of numerous anti-aging drugs, facilitating the identification of reactive metabolites that may pose safety concerns. We utilize advanced software to analyze large datasets, ensuring characterization of drug metabolism and reactive metabolite formation.
Our Metabolite Identification Platforms
CD BioSciences employs advanced technical tools and methodologies to ensure high-quality metabolite identification.
- High-performance liquid chromatography (HPLC). We help clients separate metabolites from complex biological matrices for further analysis.
- Liquid chromatography-mass spectrometry (LC-MS). We use LC-MS as a powerful integrated platform for metabolite detection and quantification. This combined technique enables the efficient separation of complex biological samples via LC, while MS provides detailed molecular characterization, guiding anti-aging drug design and optimization.
- Gas chromatography-mass spectrometry (GC-MS). We offer GC-MS for analyzing volatile and semi-volatile metabolites with high sensitivity and specificity.
- Nuclear magnetic resonance (NMR) spectroscopy. We utilize NMR spectroscopy for structure-based profiling of metabolites, unveiling their molecular architecture and contributing to the elucidation of metabolic pathways.
Identifying drug metabolites is a vital step in the anti-aging drug development process. CD BioSciences offers a suite of metabolite identification services to meet the needs of pharmaceutical researchers. If you are interested in our services, please feel free to contact us or make an online inquiry.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
