Nicotinamide Mononucleotide (NMN) Supplement R&D Services

Nicotinamide mononucleotide (NMN) has emerged as a pivotal compound in anti-aging research and supplement development. This nucleotide, a niacin derivative, plays a crucial role in cellular metabolism and energy production by serving as a nicotinamide adenine dinucleotide (NAD⁺) precursor. As individuals age, NAD⁺ levels decline, leading to age-related physiological changes, such as decreased cellular function, increased oxidative stress, and impaired metabolism. Research indicates that supplementing with NMN can effectively restore NAD⁺ levels, potentially mitigating the effects of aging.

Fig. 1 The changes in NAD⁺ levels during aging (a), the approaches to restoring NAD⁺ levels (b), and the health benefits of restoring NAD⁺ levels by NMN supplementation (c). (Song Q, et al., 2023)

CD BioSciences offers a comprehensive suite of R&D services to advance the development of NMN supplements as promising anti-aging interventions.

Overview of Our NMN Supplement R&D Services

NMN synthesis and safety evaluation

Our company offers NMN synthesis services based on chemical synthesis, microbial fermentation, and enzymatic synthesis technologies, enabling high purity, high yield, and product stability. To ensure safety for long-term use in aging populations, we offer comprehensive safety evaluations, including acute and chronic toxicity tests, allergenicity assessments, and dosage optimization studies.

Analysis of NAD concentration after NMN administration

Understanding how NMN supplementation impacts NAD⁺ levels is central to validating its anti-aging potential. We employ high-performance liquid chromatography (HPLC) and mass spectrometry (MS) to quantify NAD⁺ in biological samples.

Analysis of the Effects of NMN Supplements on Age-Related Physiological Changes

Aging is associated with various physiological changes, including reduced muscle mass, cognitive decline, and increased inflammation. Using in vivo and in vitro models, we help clients evaluate whether NMN supplements mitigate these age-related changes.

• Muscle regeneration and strength. We help clients evaluate the effects of NMN on muscle mass and strength in aging models. We also provide services to measure parameters such as muscle fiber composition, regeneration rates following injury, and overall physical performance.
• Physical activity and endurance. Using treadmill tests, voluntary wheel running, and endurance assessments in aged animals, we evaluate whether NMN supplements can improve stamina, mobility, and overall daily activity levels.
• Eye function. We examine the effects of NMN supplements on age-related ocular decline, such as retinal degeneration, lens opacity, and optic nerve health. Our experts use electroretinography (ERG), optical coherence tomography (OCT), and histological analysis to determine whether NMN can preserve visual acuity and protect against age-related eye diseases.
• Cognitive function. We offer behavioral tests and cognitive assessments to help clients understand the effects of NMN on preserving memory, enhancing learning capacity, and protecting against aging-related neurodegeneration.
• Metabolic health. We also analyze the effects of NMN on insulin sensitivity, glucose tolerance, lipid profiles, and inflammatory biomarkers, which play crucial roles in the aging process.

Through rigorous research, high-purity synthesis, comprehensive anti-aging efficacy evaluation, and safety evaluation, CD BioSciences is committed to advancing the development of NMN supplements as a promising anti-aging intervention. If you are interested in our services, please feel free to contact us or make an online inquiry.

References

1. Song Q, et al. The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update. Adv Nutr, 2023, 14 (6): 1416-1435.
2. Mills KF, et al. Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell Metab, 2016, 24 (6): 795-806.