Aging is a complex biological process characterized by a gradual decline in physiological functions and increased susceptibility to aging-related diseases. The Wnt signaling pathway has emerged as a critical player in regulating cellular processes that influence aging, including cell proliferation, differentiation, and survival.
Fig. 1 Possible involvement of Wnt signaling in organismal aging. (Naito AT, et al., 2010)
CD BioSciences specializes in helping clients develop novel anti-aging drugs targeting the Wnt pathway to combat cellular senescence and mitigate aging-related diseases. We integrate mechanistic analysis, drug screening and optimization services, and preclinical models to accelerate clients' anti-aging drug discovery pipeline.
Our Solutions for Discovering Anti-Aging Drugs Targeting Wnt
Wnt pathway modulator development services
At CD BioSciences, our experts help clients develop small molecules and biologics to modulate Wnt signaling. For example, we help clients develop small molecules that stabilize β-catenin or block Wnt ligand palmitoylation to modulate Wnt signaling in aging.
Advanced drug screening and validation platforms
CD BioSciences establishes advanced drug screening and validation platforms to facilitate the discovery of effective anti-aging drugs. Our high-throughput screening services enable rapid evaluation of large-scale compound libraries against Wnt. Additionally, we use in vitro and in vivo models to validate the efficacy and safety of drug candidates.
Custom models for preclinical studies in aging and aging-related diseases
CD BioSciences offers custom models for preclinical studies in aging and aging-related diseases, enabling the evaluation of drug efficacy and safety. For instance, we provide aging-related neurodegenerative and cardiovascular disease models, enabling comprehensive analyses of therapeutic potential and mechanisms of action.
Targeting Wnt in Aging-Related Neurodegenerative Diseases
The dysregulation of the Wnt signaling pathway has been implicated in the pathogenesis of aging-related neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases. CD BioSciences is committed to helping clients develop drugs targeting the Wnt pathway to mitigate neurodegeneration and promote neuroprotective effects in aging. We offer a range of behavioral assessments to evaluate the effects of drug candidates on neurodegenerative symptoms, including Morris water maze, novel object recognition, rotarod tests, open field tests, elevated plus maze, and forced swim tests. Additionally, we quantify neuronal biomarkers to assess the impact of these drug candidates on neuronal health and function.
Targeting Wnt in Aging-Related Cardiovascular Diseases
Aging significantly contributes to cardiovascular diseases, including myocardial cell hypertrophy, cardiac fibrosis, and vascular calcification. The Wnt signaling pathway plays a crucial role in these processes. CD BioSciences works with clients to develop targeted therapeutics that can modulate Wnt signaling to combat these aging-related cardiovascular diseases. To evaluate the potential of these drug candidates, we offer preclinical models to assess drug efficacy on key parameters, such as myocardial function, fibrosis levels, and vascular integrity. We provide comprehensive biomarker analysis services to measure the impact of drug candidates on cardiovascular health, assisting clients in evaluating inflammatory markers, fibrosis-related proteins, and indicators of vascular health.
CD BioSciences is dedicated to advancing the field of anti-aging drug discovery targeting the Wnt pathway through innovative approaches. If you are interested in our services, please feel free to contact us or make an online inquiry.
References
- Naito AT, et al. Wnt signaling and aging-related heart disorders. Circ Res, 2010, 107 (11): 1295-303.
- Maiese K, et al. The Wnt signaling pathway: aging gracefully as a protectionist? Pharmacol Ther, 2008, 118: 58-81.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
