Silent mating type information regulation 2 homolog 1 (SIRT1) is a member of the sirtuin family of NAD+-dependent deacetylases that play a pivotal role in regulating cellular processes associated with aging and longevity. SIRT1 regulates several age-related processes, including DNA repair, inflammation, and metabolic homeostasis. Its activity is known to decline with age, contributing to the progression of various age-related diseases.
Fig. 1 The role of SIRT1 in health and aging. (Rogina B and Tissenbaum HA, 2024)
As a key regulator of gene expression and metabolism, the SIRT1 signaling pathway has emerged as a promising target for the development of anti-aging therapeutics. CD BioSciences is dedicated to offering anti-aging drug discovery services targeting the SIRT1 signaling pathway, leveraging our deep understanding of SIRT1's role in aging.
How Do We Screen For Anti-Aging Drugs Targeting Nrf2?
Effective screening methods are crucial for identifying potential anti-aging drugs targeting the SIRT1 signaling pathway. CD BioSciences offers a multi-faceted approach to drug screening.
High-throughput screening
We utilize advanced high-throughput screening technologies to identify natural and synthetic compounds that activate the SIRT1 pathway. Our experts use SIRT1-specific substrates and fluorometric assays to quantify deacetylation activity. Our extensive compound libraries allow for the efficient evaluation of thousands of potential activators.
In vitro assays
We provide in vitro assays to evaluate the impact of drug candidates on the cellular senescence models, including assessments of oxidative stress, inflammation, and metabolic function. We facilitate the advancement of promising candidates through our comprehensive evaluation services to subsequent stages of development.
Types of Anti-Aging Drugs Targeting SIRT1 We Can Develop
SIRT1 activators
We assist clients in discovering SIRT1 activators that enhance SIRT1 enzymatic activity, leading to increased deacetylation of target proteins involved in cellular stress response, metabolism, and longevity. Furthermore, we offer medicinal chemistry services to synthesize and optimize these molecules for potency, selectivity, and favorable pharmacokinetic properties.
Types of Anti-Aging Supplements Targeting SIRT1 We Can Develop
NAD+ precursors
We offer NAD+ precursor discovery services, including identifying nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), to elevate intracellular NAD+ levels and enhance the activity of the SIRT1 pathway.
Evaluation of the Effects of Anti-Aging Drugs Targeting SIRT1
Evaluation of the effects of drugs on cell regeneration
We help clients customize in vitro models to investigate the effects of anti-aging drugs targeting the SIRT1 pathway on diverse cell types. We employ a range of assays to quantify key indicators of cell regeneration, such as cell viability, cell proliferation, and senescence-associated β-galactosidase activity, providing a comprehensive evaluation of drug efficacy.
Evaluation of the effects of drugs on age-related diseases
We help clients evaluate the efficacy of anti-aging drugs targeting the SIRT1 pathway in age-related diseases, such as Alzheimer's disease, diabetes, and cardiovascular diseases.
CD BioSciences has extensive and successful experience in the development of anti-aging drugs targeting the SIRT1 signaling pathway. If you are interested in our services, please feel free to contact us or make an online inquiry.
Reference
- Rogina B, Tissenbaum HA. SIRT1, resveratrol and aging. Front Genet, 2024, 15: 1393181.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
