p53 is a transcription factor that orchestrates cellular responses to stress, including DNA damage and oxidative stress. Its activation leads to cell cycle arrest, senescence, or apoptosis, which are crucial for maintaining cellular integrity. During aging, dysregulation of p53 can contribute to the decline in tissue homeostasis and regenerative capacity. Studies have shown that p53 levels increase with age, correlating with the accumulation of cellular damage. This relationship underscores the potential of developing anti-aging drugs targeting p53.
Fig. 1 A model for regulating cellular senescence, ageing, and age-related disorders by full-length p53 and p53 isoforms. (Fujita K, 2019)
CD BioSciences assists clients in developing innovative anti-aging drugs by focusing on the multiple roles of the p53 pathway in cellular senescence and metabolism.
How Do We Identify P53 as an Anti-Aging Target?
Analysis of p53-mediated senescence pathway
Our services are focused on the intricate network of signaling pathways regulated by p53. Leveraging proteomics and genomics techniques, we enable our clients to identify critical aging-related pathways modulated by the p53 pathway.
Analysis of the role of p53 in ribosome biogenesis in aging
Ribosome biogenesis is essential for protein synthesis and cell growth. We help clients explore the role of the p53 pathway in regulating ribosome biogenesis, which is often dysregulated in aging cells. We aim to help clients develop drugs that restore normal ribosome function and delay aging by targeting the p53 pathway.
Analysis of the role of p53 in glucose metabolism during aging
Glucose metabolism is another critical aspect of aging that is influenced by p53. As organisms age, they often experience a decline in glucose metabolism, leading to insulin resistance and metabolic syndrome. We focus on assisting clients in understanding how the p53 pathway regulates glucose metabolism and identifying potential drug targets to mitigate these age-related changes.
Analysis of the role of p53 in caloric restriction in aging
Caloric restriction has been shown to extend lifespan and improve healthspan in various model organisms. The p53 is known to play a role in the beneficial effects of caloric restriction. At CD BioSciences, we are actively helping our clients investigate the molecular mechanisms by which p53 mediates the anti-aging effects of caloric restriction, with the aim of developing drugs that can mimic these effects.
Types of Anti-Aging Drugs Targeting p53 We Can Develop
At CD BioSciences, our expertise in anti-aging drug discovery is grounded in a deep understanding of the p53 pathway and its implications for aging. We provide comprehensive drug discovery services tailored to targeting the p53 signaling pathway.
Small molecule inhibitors
CD BioSciences provides high-throughput screening (HTS) services to identify small molecules that can inhibit the p53 signaling pathway. Once promising leads are identified, we help clients perform lead optimization.
We help clients measure the effects of compounds on cellular senescence markers. Additionally, we use in vivo aging models (e.g., mice, worms) to assess the impact of p53 inhibitors on lifespan and age-related phenotypes.
Biologics
CD BioSciences offers comprehensive antibody discovery services. We utilize advanced technologies such as phage display and ribosome display to identify monoclonal antibodies that can target the p53 pathway or its downstream effectors. Our services include cloning, expressing, purifying, and characterising these antibodies. Our experts also help clients assess the long-term effects of biologics on lifespan in various models.
At CD BioSciences, our team combines expertise in molecular biology, pharmacology, and bioinformatics to help clients accelerate the discovery of effective anti-aging therapeutics targeting the p53 signaling pathway. If you are interested in our services, please feel free to contact us or make an online inquiry.
References
- Hasty P, Christy BA. p53 as an intervention target for cancer and aging. Pathobiol Aging Age Relat Dis, 2013, 3.
- Fujita K. p53 Isoforms in Cellular Senescence- and Ageing-Associated Biological and Physiological Functions. Int J Mol Sci, 2019, 20 (23): 6023.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
