cAMP response element binding protein-regulated transcription coactivator (CRTC) proteins, including CRTC1, CRTC2, and CRTC3, are activated by various kinases in response to cellular stress and nutritional signals. They play a crucial role in the transcriptional regulation of genes involved in energy homeostasis and stress responses. As organisms age, the altered expression and activity of CRTC proteins may lead to impaired metabolic function and increased cellular stress, contributing to the aging process.
Fig. 1 CRTC-1 is a longevity-specific AMPK target that uncouples growth, reproduction, and stress resistance from lifespan extension. (Burkewitz K, et al., 2015)
At CD BioSciences, our anti-aging drug discovery services are designed to support the development of novel therapeutics targeting CRTC signaling pathways. Our team has extensive expertise in molecular biology, pharmacology, and bioinformatics to offer a robust approach to anti-aging drug discovery.
How Do We Identify CRTC as an Anti-Aging Target?
CD BioSciences employs a multidisciplinary approach to identify and validate CRTC as an anti-aging target for drug discovery.
Bioinformatic analysis
We utilize bioinformatics tools to analyze large datasets and identify patterns and correlations between CRTC expression and aging-related phenotypes. We also map the complex signaling networks involving CRTC to understand their role in the broader context of aging and disease.
Experimental validation
CD BioSciences uses a variety of cellular models to study the impact of CRTC modulation on cellular senescence. We also help clients validate the findings in vivo using appropriate animal models to study the effects of CRTC modulation on lifespan and healthspan.
How Do We Develop Anti-Aging Drugs Targeting CRTC?
CD BioSciences offers a comprehensive suite of services to help clients discover and develop anti-aging drugs that target the CRTC signaling pathway. We perform high-throughput screening (HTS) to identify small molecules that can inhibit CRTC. Our experts help clients optimize these hits, preparing them for preclinical testing. We also help clients investigate the mechanisms by which these compounds influence aging-related pathways.
Targeting CRTC in Aging-Related Diseases
Aging-related metabolic disease
CRTC proteins play a significant role in regulating glucose and lipid metabolism. We help clients develop anti-aging drugs targeting the CRTC pathway to improve insulin sensitivity and glucose tolerance, potentially reversing the progression of type 2 diabetes. We also assist in developing drugs targeting CRTC to reduce the accumulation of fatty acids and triglycerides, thereby decreasing the risk of obesity.
Aging-related cardiovascular diseases
CRTC proteins are involved in the pathological processes underlying cardiovascular disease, such as hypertrophy and fibrosis. We help clients develop anti-aging drugs targeting the CRTC pathway to inhibit cardiac hypertrophy and reverse fibrotic changes.
At CD BioSciences, our expertise in identifying and validating novel targets, coupled with our robust drug discovery platforms, positions us as a reliable partner in the development of anti-aging drugs. If you are interested in our services, please feel free to contact us or make an online inquiry.
References
- Burkewitz K, et al. Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal. Cell, 2015, 160 (5): 842-855.
- Escoubas CC, et al. Deregulation of CRTCs in Aging and Age-Related Disease Risk. Trends Genet, 2017, 33 (5): 303-321.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
