Age-related eye diseases are a leading cause of visual impairment and blindness globally, significantly impacting the quality of life in the elderly. To accelerate the development of effective therapies, there is an urgent need for custom animal models that replicate the pathophysiological features of age-related eye diseases. Rodent models, particularly genetically engineered mice, offer cost-effective and genetically tractable systems for studying ocular diseases. In contrast, larger species such as pigs and rabbits provide greater anatomical and physiological similarity to the human eye, making them valuable for preclinical evaluation of ophthalmic therapies.
Fig. 1 The effects of aging on the eyes. (You L, et al., 2024)
CD BioSciences offers a full suite of age-related eye disease modeling services tailored to the needs of clients from pharmaceutical companies and academic organizations. Each model is developed in mice, rabbits, pigs, or non-human primates (NHPs) and validated for its relevance to human ocular pathophysiology. Comprehensive support is available through advanced imaging, functional assessments, and molecular analysis platforms.
Our Age-Related Eye Disease Modeling Services
CD BioSciences offers a comprehensive range of custom animal models for age-related macular degeneration (AMD) research, enabling clients to investigate both wet (neovascular) and dry (atrophic) AMD. Our company offers animal models of wet age-related macular degeneration (AMD) developed through methods such as subretinal injection-induced choroidal neovascularization (CNV), VEGF/bFGF-eluting scleral pellets, or surgical rupture of Bruch's membrane. These models are widely used for evaluating anti-VEGF drugs, anti-inflammatory agents, and gene therapies. For dry AMD research, we provide NaIO3-induced retinal degeneration models and senescence-accelerated mouse strains, which closely mimic retinal pigment epithelium (RPE) atrophy, photoreceptor loss, and oxidative stress.
Our company provides specialized cataract model customization services to support the evaluation of novel anti-cataract therapies targeting oxidative stress, protein aggregation, and metabolic dysregulation. We offer genetically engineered mouse models, such as LEGSKO mice, Grx2 knockout mice, SDH-deficient mice, and Nsdhl-mutant mice, and chemically induced cataract models. These models enable mechanism studies and therapeutic testing across diverse pathways implicated in age-related cataract.
CD BioSciences' Animal Model Supporting Services
CD BioSciences provides support services that validate and characterize age-related eye disease models and enable preclinical evaluation of therapeutic candidates.
- Model characterization services. We help clients characterize age-related eye disease animal models by confirming key pathological and functional features, such as choroidal neovascularization extent and leakage, retinal layer thinning, RPE degeneration, photoreceptor loss, and associated visual function decline.
- In vivo drug efficacy evaluation. Our company offers drug efficacy evaluation services for small molecules, biologics, and gene therapies, with endpoints that assess therapeutic impact on ocular structure and function.
- Histopathology services. We offer standardized histopathological evaluation and severity grading of retinal layers, retinal pigment epithelium (RPE), and lens fiber architecture to assess aging-related structural changes.
CD BioSciences offers custom age-related eye disease modeling services and comprehensive preclinical services that empower researchers evaluating novel therapeutic candidates and conducting mechanistic studies. If you are interested in our services, please feel free to contact us or make an online inquiry.
Reference
- You L, et al. The Impact of Aging on Ocular Diseases: Unveiling Complex Interactions. Aging Dis, 2024.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
