Aging kidneys undergo significant structural and functional changes, characterized by a decline in nephron number, glomerulosclerosis, tubulointerstitial fibrosis, and impaired renal function. These changes can lead to increased susceptibility to injury and chronic conditions. The development of effective models to study the aging kidney has become increasingly important.
Fig. 1 Schematic structural and functional changes in the aging kidney. (Noronha IL, et al., 2022)
CD BioSciences helps clients customize aging kidney models using various species and techniques. Our models provide a platform for studying the underlying mechanisms of renal aging, assessing drug efficacy, and exploring potential anti-aging therapeutics.
In Vitro and In Vivo Models of Aging Kidney
Aging models of renal tubular epithelial cells
Renal tubular epithelial cells (RTECs) are critical in reabsorption and secretion. CD BioSciences offers custom aging models of renal tubular epithelial cells that reflect the cellular senescence observed in aging kidneys. We develop these models to target specific nephron segments, including the proximal tubules, distal tubules, and collecting ducts, and incorporate genetic modifications associated with aging to meet diverse research needs. Our models exhibit key characteristics such as increased SA-β-galactosidase activity, altered gene expression profiles, and changes in cellular morphology. Our models allow clients to assess the impact of aging on RTEC function, susceptibility to injury, and responses to potential therapeutics.
Rat models of aging kidney
Our company offers customized rat models of aging kidney, which replicate the physiological changes associated with aging, including reductions in glomerular filtration rate (GFR) and alterations in renal blood flow. We offer longitudinal monitoring and detailed characterization of age-related changes. We support clients in exploring the effects of various anti-aging therapeutics on renal aging and function in these models.
Klotho knockout (KO) mice
Klotho, a gene strongly linked to aging and longevity, plays a crucial role in renal function. CD BioSciences provides customized Klotho knockout mice to investigate the specific contributions of Klotho deficiency to the age-related decline of kidney function. These models enable research to focus on the impact of Klotho deficiency on key aspects of renal aging, providing valuable insights into the development of anti-aging drugs.
Canine models of aging kidney
Canine kidneys exhibit similarities to human kidneys, making them valuable large animal models for studying age-related changes in renal structure and function. CD BioSciences offers custom canine models of aging kidney to support preclinical research. These models enable clients to investigate renal aging within the complex physiological context of a large mammalian system.
How Do We Choose the Right Models of the Aging Kidney?
By selecting the right model of aging kidneys, our clients can advance their understanding of renal aging and develop effective therapeutics.
- Research objective. Are you investigating cellular mechanisms, testing drug efficacy, or exploring genetic factors? Each model offers distinct advantages depending on the research focus.
- Species relevance. Researchers should consider the species that represent the physiological and pathological conditions of interest. For example, rodent models are often used for mechanism studies, while canine models may be more suitable for translational research.
CD BioSciences is committed to providing high-quality custom models of aging kidneys that support innovative research and help address the challenges of age-related kidney diseases. If you are interested in our services, please feel free to contact us or make an online inquiry.
References
- Bowman BT and Abdel-Rahman EM. Models of Aging Kidney. Conn's Handbook of Models for Human Aging, 2018, 863-871.
- Noronha IL, et al. Glomerular filtration in the aging population. Front Med (Lausanne), 2022, 9: 769329.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
