Insulin is a potent anabolic hormone that plays a crucial role in regulating glucose metabolism and maintaining homeostasis within the body. Alterations in insulin levels are commonly observed during the aging process and have important implications for understanding age-related physiological changes. Experimental studies in various animal models of aging have provided intriguing insights into the role of insulin and insulin signaling in the aging process and longevity. These findings have important implications for understanding age-related diseases in humans.
Fig. 1 Elevated insulin levels and insulin resistance favor age-associated diseases in humans. (Kolb H, et al., 2023)
As a highly experienced contract research company in aging, CD BioSciences is proud to offer comprehensive insulin level analysis services tailored for evaluating aging in animal models.
Sample Preparation and Requirements
Our experienced team has developed robust protocols to ensure the reliable and reproducible measurement of insulin concentrations. We are equipped to analyze a variety of biological samples, including plasma, serum, and tissue homogenates. We provide specific instructions on the collection method, sample volume requirements, and the use of appropriate collection tubes or vials to prevent sample degradation.
How Do We Analyze Insulin Level in Aging?
At CD BioSciences, we employ advanced techniques to measure insulin levels in aging models.
Insulin quantification
We utilize highly sensitive and specific immunoassays, such as enzyme-linked immunosorbent assay (ELISA) or radioimmunoassay (RIA), to quantify insulin levels in the samples. Our methods provide reliable and reproducible results, allowing clients to detect even subtle changes in insulin concentrations.
Age-dependent insulin profiles
We help clients establish age-dependent insulin profiles by analyzing insulin levels across animal models of different age groups. Our services are crucial for understanding the dynamic changes in insulin homeostasis in aging and identifying potential biomarkers or targets for anti-aging intervention.
Tissue-specific insulin analysis
We also analyze insulin levels and signals in specific tissues, such as the liver, muscle, or adipose tissue, to assist clients in understanding the local effects of aging on insulin homeostasis.
Deliverables of Our Insulin Level Analysis Services
At CD BioSciences, we are committed to providing our clients with comprehensive and informative deliverables, including the following:
- Analysis methods. We offer a description of the insulin quantification method used in the experiment, including the assay principles and instrumentation.
- Insulin concentration data. We present the measured insulin levels for each sample in a clear and organized format.
- Statistical analysis. Depending on the client's requirements, we can perform reliable statistical analyses to support interpretation of the insulin level data, such as mean, standard deviation, and standard error calculations.
CD BioSciences is committed to delivering high-quality, reliable, and customer-centric insulin level analysis services for evaluating aging in animal models. If you are interested in our services, please feel free to contact us or make an online inquiry.
Reference
- Kolb H, et al. Insulin and aging - a disappointing relationship. Front Endocrinol (Lausanne), 2023, 14: 1261298.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
