Genetic Modification Services in Cellular Senescence Models
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Genetic Modification Services in Cellular Senescence Models


Cellular senescence is a state where cells cease to divide but remain metabolically active, playing crucial roles in aging, tissue repair, and tumor suppression. Genetic modification in cellular senescence models involves altering specific genes or pathways to study the mechanisms underlying senescence and its implications.

At CD BioSciences, a leading provider of innovative research solutions, we offer comprehensive genetic modification services in cellular senescence models. Leveraging our expertise in molecular biology and advanced genetic engineering techniques, we aim to elucidate key genes and pathways involved in cellular senescence and provide valuable insights into the development of potential therapeutic interventions.

Concept diagram of genetically modified cellular senescence models.

Key Genes and Pathways in Cellular Senescence We Focus On

In our genetic modification services in cellular senescence models, we focus on investigating key genes and pathways that regulate and contribute to cellular senescence as follows.

Key pathways Our services
Insulin/IGF-1 pathway We investigate key genes involved in this pathway, including insulin receptor (INSR), insulin receptor substrate (IRS), and downstream signaling components. Our services aim to help clients understand how insulin/IGF-1 signaling influences cellular senescence and identify potential interventions to modulate this pathway.
mTOR pathway The mechanistic target of the rapamycin (mTOR) pathway is a central regulator of cell growth, metabolism, and autophagy. Our services focus on key genes in the mTOR pathway, including mTOR itself, as well as downstream effectors such as S6K and 4E-BP1.
AMPK pathway The AMP-activated protein kinase (AMPK) pathway is an energy-sensing pathway that regulates cellular metabolism and homeostasis. We help clients investigate key genes in the AMPK pathway, including AMPK subunits (α, β, γ), as well as upstream regulators such as LKB1 (liver kinase B1) and AMP/ATP ratio sensors such as AMPK kinases.

Overview of Our Genetic Modification Services

At CD BioSciences, we utilize genetic engineering techniques to perform efficient modifications in cellular senescence models.

CRISPR/Cas9 editing services

We offer gene editing services using CRISPR/Cas9 technology to create genetically modified senescent cell lines, allowing for research on specific genes involved in senescence regulation. Our services generate knockout, knock-in, or point mutation cell lines for studying the impact of specific gene alterations on the senescence process.

Gene knockdown services

We offer gene knockdown services using RNA interference (RNAi) and short hairpin RNA (shRNA) strategies to transiently silence gene expression in senescent cells, enabling the investigation of gene function in the senescence process.

Overexpression services

We utilize viral vectors and transfection techniques to introduce exogenous genes into senescent cells. By overexpressing key genes involved in cellular senescence, we can assess their impact on senescence-associated phenotypes and unravel their roles in the underlying molecular mechanisms.

Deliverables of Our Genetic Modification Services

Our genetic modification services in cellular senescence models offer a range of deliverables to support the client's research goals.

  • Customized experimental proposal. Our team of experienced scientists works closely with you to understand the client's specific research objectives and tailor the genetic modification strategies to meet their requirements.
  • Genetically modified cellular senescence models. We provide genetically modified cellular senescence models with precise gene modifications. Our models serve as valuable tools for investigating the function of specific genes and pathways in cellular senescence.
  • Characterization and validation data. We deliver comprehensive characterization and validation data for the genetically modified cellular senescence models. We provide detailed analyses of gene expression, protein levels, cellular morphology, and functions relevant to cellular senescence. Our expert scientists utilize advanced techniques such as microscopy, flow cytometry, and next-generation sequencing to provide reliable data.

CD BioSciences is dedicated to providing high-quality genetic modification services in cellular senescence models. With our expertise, advanced tools, and commitment to scientific excellence, we are your trusted partner in advancing cellular senescence research and driving innovative discoveries in the field. If you are interested in our services, please feel free to contact us or make an online inquiry.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.