Lung aging is characterized by structural and functional changes, including decreased elasticity, altered airway responsiveness, and impaired gas exchange. These changes can lead to diseases such as chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis. Key factors contributing to lung aging include oxidative stress, inflammation, and the accumulation of senescent cells. Developing reliable models that mimic these age-related changes is essential for advancing our understanding of lung biology and disease mechanisms.
Fig. 1 Lung fibrosis under the influence of aging. (Wang Y, et al., 2024)
CD BioSciences specializes in customizing lung aging models that facilitate comprehensive research and drug discovery in this vital area. Our expertise encompasses a range of in vitro and in vivo models, customized to address specific research objectives.
What Custom Models of Aging Lung Do We Offer?
Models of the aged lung epithelium
CD BioSciences offers custom models of aged lung epithelium, which are crucial for studying the effects of aging on airway function and response to injury. Our customization services include selecting specific epithelial cell types (e.g., alveolar type I and II cells) and inducing with bleomycin.
We help clients use models of the aged lung epithelium to explore the alterations of cellular behavior, including changes in cell proliferation, cell differentiation, and cellular secretion. Our models help clients investigate the impact of aging on epithelial barrier function, susceptibility to pathogens, and responses to therapeutic agents.
Pulmonary fibrosis murine models with natural aging
For in vivo studies, CD BioSciences offers pulmonary fibrosis models using NOD/SCID mice. The natural aging process in these models ensures high physiological relevance and reflection of the complex temporal dynamics of fibrosis development. Our company offers longitudinal monitoring and detailed characterization of these models, enabling meticulous investigation of age-related changes.
Senescence-accelerated mouse (SAM) models of the aging lung
The SAM is a well-established model for studying aging and age-related diseases. CD BioSciences offers custom services using SAM-P/2 to examine the effects of aging on lung function and the development of pulmonary diseases. Our models exhibit accelerated aging characteristics, making them ideal for studying senescence-related changes in lung physiology.
Applications of Models of Aging Lung in Research and Development
- Understanding disease mechanisms. Our models of aging lung provide insights into the fundamental mechanisms underlying age-related lung diseases, such as COPD and pulmonary fibrosis, enabling researchers to identify potential therapeutic targets.
- Evaluating drug efficacy. Our custom lung aging models serve as tools for evaluating the efficacy and safety of novel drug candidates targeting aging-related diseases. These models enable researchers to assess whether therapeutics to mitigate the effects of lung aging and to identify potential adverse effects during preclinical development.
CD BioSciences is committed to offering custom models of aging lung that support a range of applications, including mechanism studies and drug screening. Our end-to-end services, encompassing model design and development, data analysis, and reliable results, equip clients with reliable insights to accelerate their research into age-related lung diseases. If you are interested in our services, please feel free to contact us or make an online inquiry.
References
- Ma Z, et al. A novel pulmonary fibrosis NOD/SCID murine model with natural aging. BMC Pulm Med, 2024, 24 (1): 457.
- Wang Y, et al. The aging lung: microenvironment, mechanisms, and diseases. Front Immunol, 2024, 15: 1383503.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
