Alkaloids are a diverse class of naturally occurring plant compounds known for their wide-ranging biological activities. These nitrogen-containing compounds are well-known for their biological activity, making them valuable in medicinal chemistry and nutraceutical applications. Among the various benefits of alkaloids, many have shown potential anti-aging properties mediated by their antioxidant, anti-inflammatory, and neuroprotective effects.
Fig. 1 Main classes of alkaloid precursors and derivatives. (Iriti M and Faoro F, 2009)
CD BioSciences, with decades of experience in R&D services, specializes in alkaloid research and offers comprehensive services to help clients develop anti-aging supplements.
What Types of Alkaloids Do We Use in Anti-Aging Supplement Development?
CD BioSciences specializes in the development of anti-aging supplements in which alkaloids serve as the primary active ingredients. For example, we help clients develop berberine (BBR) supplements that have been shown to extend lifespan in model organisms by enhancing cellular energy metabolism and reducing inflammation. Additionally, our experts also analyze the role of caffeine in modulating key pathways related to aging, including autophagy and mitochondrial function.
Overview of Our Alkaloid Supplement R&D Services
Extraction and purification of alkaloids
CD BioSciences offers extraction and purification services to isolate high-purity alkaloids from plant sources. Our experts use various chromatographic techniques, including high-performance liquid chromatography (HPLC) and liquid-liquid extraction methods, to isolate and purify alkaloids with high specificity.
Alkaloid synthesis services
In addition to natural extraction, we provide synthetic and semi-synthetic approaches to develop alkaloids. By structurally modifying natural alkaloids, we help improve their bioavailability, stability, and activity in delaying cellular and molecular hallmarks of aging, supporting the development of novel supplements for healthy aging.
Formulation development services
Our formulation expertise focuses on supporting the effective use of alkaloids in anti-aging supplement development. Through advanced delivery systems and bioavailability optimization, we assist clients in developing stable, effective formulations that support physiological functions associated with healthy aging and overall wellness.
Evaluation of Anti-Aging Effects of Alkaloid Supplements
Our company provides comprehensive preclinical studies to evaluate the anti-aging potential of alkaloid supplements. Using both in vitro and in vivo aging models, we investigate how specific alkaloid supplements influence key parameters of healthy aging, including lifespan, stress resistance, and healthspan. Our services enable clients to identify whether these supplements enhance resilience against oxidative and metabolic stress and preserve tissue and organ function over time.
In addition, we offer mechanistic analyses to uncover the molecular and cellular pathways through which alkaloid supplements exert their longevity-promoting effects. Our analyses focus on core aging-related processes such as autophagy, apoptosis, mitochondrial function, and cellular senescence, enabling a deeper understanding of how alkaloid supplements contribute to extending lifespan and improving healthspan.
At CD BioSciences, we are committed to advancing alkaloid research and development. Our extensive expertise in the extraction, synthesis, formulation, and efficacy evaluation of alkaloid supplements enables us to serve as a reliable partner in supporting anti-aging research. If you are interested in our services, please feel free to contact us or make an online inquiry.
References
- Wenli S, et al. Traditional Iranian and Arabic Herbal Medicines as natural anti-cancer drugs. Agrociencia, 2020, 54: 129-142.
- Iriti M, Faoro F. Chemical diversity and defense metabolism: how plants cope with pathogens and ozone pollution. Int J Mol Sci, 2009, 10 (8): 3371-3399.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
