Epigallocatechin Gallate (EGCG) Supplement R&D Services

Epigallocatechin gallate (EGCG) is a highly potent polyphenol found primarily in green tea. It is renowned for its vast array of health-promoting properties and potential impact on aging and chronic diseases. Increasing research has explored the potential role of EGCG in modulating key processes associated with aging, including oxidative stress, chronic low-grade inflammation, mitochondrial function, and cellular stress responses, positioning it as a compound of interest in healthy aging research.

Fig. 1 Chemical Structure of EGCG and its progenitors. The chemical makeup of EGCG contributes to its ROS-reducing and anti-inflammatory properties. (Payne A, et al., 2022)

CD BioSciences offers a multidisciplinary approach to the research and development of EGCG supplements. By emphasizing mechanisms such as oxidative stress reduction, inflammation control, and neuroprotection, we support the development of EGCG supplement formulations that contribute to healthy aging and extended lifespan.

Overview of Our Epigallocatechin Gallate R&D Services

Extraction of epigallocatechin gallate from green tea

At CD BioSciences, we offer optimized extraction and purification strategies to preserve the bioactivity of EGCG, ensuring high-quality raw materials for the development of anti-aging supplements.

Epigallocatechin gallate chemical synthesis services

In addition to natural extraction, CD BioSciences offers chemical synthesis services to produce EGCG. We generate efficient synthetic pathways with appropriate intermediates and catalysts to produce EGCG with high purity while minimizing by-products.

Formulation development services

We specialize in supporting the development of EGCG formulations with improved stability and bioavailability. By leveraging advanced formulation and evaluation technologies, we assist clients in assessing the potential of EGCG supplements to support healthy aging, including studies related to oxidative stress, inflammation, and age-associated functional changes.

Evaluation of the Effects of Epigallocatechin Gallate Supplement in Neuroprotection and Cognitive Aging

EGCG has emerged as a promising health supplement in preventing aging-related neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. Its diverse biological activities target key hallmarks of brain aging, including oxidative stress, chronic inflammation, amyloid accumulation, and tau pathology.

• Antioxidant and anti-inflammatory effects. Aging brains are particularly vulnerable to oxidative damage and inflammaging, which accelerate neuronal decline. Through assays that measure reactive oxygen species (ROS) levels and antioxidant enzyme activity, we help clients evaluate whether EGCG supplements protect neuronal cells from oxidative damage. Moreover, we assess its ability to reduce pro-inflammatory cytokine production, protecting neurons from inflammaging.
• Amyloid beta (Aβ) clearance. The accumulation of Aβ plaques is a hallmark of Alzheimer's and a driver of accelerated cognitive aging. We assist in analyzing whether EGCG supplements inhibit the aggregation of Aβ peptides, prevent plaque formation, and mitigate neurotoxicity.
• Neuroprotective effects. Using various biochemical and bioanalytical experiments, we help clients explore the impact of EGCG supplements on inhibiting tau hyperphosphorylation and modulating tau interactions.

CD BioSciences offers comprehensive R&D services, from extraction and synthesis to formulation development, with a strong focus on the anti-aging potential of EGCG. Our experts focus on helping clients assess the potential of EGCG supplements to mitigate aging-related oxidative stress and inflammatory processes, providing scientific data to support research and development efforts in healthy aging and longevity. If you are interested in our services, please feel free to contact us or make an online inquiry.

Reference

1. Liu B, et al. Synthesis, Stability, and Antidiabetic Activity Evaluation of (-)-Epigallocatechin Gallate (EGCG) Palmitate Derived from Natural Tea Polyphenols. Molecules, 2021, 26 (2): 393.