In Vitro ADME Services for Anti-Aging Drug Development

Understanding the absorption, distribution, metabolism, and excretion (ADME) properties of drug candidates is essential for the successful development of anti-aging therapeutics. In vitro ADME studies provide a controlled environment to evaluate pharmacokinetic behaviors early in the development pipeline, enabling the identification and elimination of inappropriate candidates before advancing to more expensive and time-consuming development stages.

At CD BioSciences, our expertise in in vitro ADME services enables us to support pharmaceutical companies in developing effective and safe anti-aging drugs. Our team works with clients to develop study designs that meet specific research goals.

Our In Vitro ADME Services for Anti-Aging Drug Development

In vitro permeability testing services for anti-aging drug development

Permeability plays a critical role in determining the oral bioavailability and systemic exposure of anti-aging drugs. Our services aim to help clients select promising drug candidates for further development.

• Caco-2 assay. Using Caco-2 cell lines, we simulate intestinal absorption to predict how anti-aging drugs permeate biological membranes. We offer the Caco-2 permeability assay to uncover drug absorption following oral administration.
• MDCK-MDR1 assay. We offer the MDCK-MDR1 assay to assess the potential of anti-aging drug candidates being substrates for P-glycoprotein (P-gp), which can influence their brain penetration and gut absorption.
• Parallel artificial membrane permeability assay (PAMPA). We also employ PAMPA to evaluate the passive permeability of anti-aging drugs.
• pH-Dependent permeability profiling. We help clients evaluate permeability over a wide pH range, which is valuable for an early understanding of how anti-aging drugs may be absorbed throughout the gastrointestinal tract.

Metabolism-related drug-drug interactions analysis services for anti-aging drug development

Drug-drug interactions (DDIs) significantly influence the pharmacokinetics and pharmacodynamics of anti-aging therapeutics. CD BioSciences offers comprehensive metabolism-related DDI analysis services, focusing on the major enzymatic pathways involved in drug metabolism, such as cytochrome P450 (CYP450) and uridine diphosphate glucuronosyltransferases (UGT).

• CYP450 inhibition and induction assays. We offer CYP450 inhibition and induction assays to evaluate the potential of anti-aging drugs to inhibit or induce specific CYP450 isoforms (e.g., CYP3A4, CYP2D6, CYP2C9), which are critical to predicting potential adverse interactions.
• UGT inhibition and induction assays. We also offer UGT inhibition and induction assays to evaluate the impact of anti-aging drugs on UGT isoforms (e.g., UGT1A1, UGT2B7), which are responsible for phase II metabolism.

In vitro characterization of anti-aging drug metabolites

Our company offers comprehensive services to help clients assess whether the potential anti-aging therapeutics are effective and safe. Using liver microsomes, we evaluate the metabolic stability and estimate the in vivo hepatic clearance of anti-aging drugs. We employ S9 fractions to assess both phase I and phase II metabolism and identify potential toxic metabolites. We also use hepatocytes to study metabolic pathways, quantify metabolites, and assess enzyme kinetics, which aids in selecting optimal drug candidates.

At CD BioSciences, we offer high-quality in vitro ADME services to accelerate the development of anti-aging drugs. Through our platform, we empower clients to make informed decisions, minimize late-stage failures, and advance safer and more effective anti-aging therapeutics. If you are interested in our services, please feel free to contact us or make an online inquiry.